Long Term Complications of DM

Beschreibung

BY205- Human Biochemistry (Metabolism) Karteikarten am Long Term Complications of DM , erstellt von Sammy Crockett am 11/12/2013.
Sammy Crockett
Karteikarten von Sammy Crockett, aktualisiert more than 1 year ago
Sammy Crockett
Erstellt von Sammy Crockett vor fast 11 Jahre
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Zusammenfassung der Ressource

Frage Antworten
Microvascular Nephropathy (Kidney) Retinopathy (Eye) Neuropathy (Nerves)
Non enzymatic protein glycation Addition of glucose to protein Rate depends on ambient glucose conc Glycation can alter protein function/break down Results in Advance Glycation End products (AGEs)
Polyol pathway and retinopathy Aldose reductase found in nerve cells and lens of eye Too much sorbitol damages the lens NADH depletion can lead to oxidative damage
Infections Lots of sugar=more susceptible to infection Peripheral tissues most at risk due to narrow blood vessels Due to microangiopathy, ischemia, immunosuppression and hyperglycemia
Nephropathy Due to glomerulosclerosis Hyaline nodules build up on walls of vessels
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