Vad kan hända när två molekyler sätts samman?

ligand

antidoter

Toxicity of a chemical depends on...

Molecular properties

Chemical prop.

Volatility

Solubility

Reactivity

Electrophiles

Observable effects

Intermolecular forces

Hur kan de minimis principle mättas?

Metabolic activation/inactivation

Reversible/irreversible effects

Toxilogical concepts

Oral (food, drinks)

Intravenous (in blood circulation)

Intraperitoneal (in abdominal cavity)

Inhalation (air)

Subcutan (under skin)

Dermal (on skin)

Transport through cell membranes

Diffusion

Facilitated diffusion

Ion channels

Paracellular transport

Absorption in the gut/intestines

Absorption through the skin

xenobiotic

Distribution of xenobiotics depends on...

Kidneys...

Excretion via the liver

Enterohepatic circulation

Two molecules that can be excreted in the lungs