Degree Neuropharmacology Flashcards on Inhibitory Transmission 1, created by Anna mph on 12/15/2015.
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Created by Anna mph
almost 9 years ago
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Created by Anna mph
almost 9 years ago
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Describe how GABA is synthesised
Where would you find GABA in long projecting neurons?
How are the actions of GABA terminated?
What is GABA broken down by?
What products of the breakdown of GABA?
How are succinic aldehyde and Glutamate broken down?
What type of channel is a GABAa channel?
Which ions flow through a GABAa channel?
Where are GABAa channels found?
What type of channel are GABAb channels?
Where are GABAb channels located
What is the structure of a GABA receptor?
What is the most common combination of subunits?
How many different types of a, B and Y are there?
Which are the most abundant of each subunit?
Where do GABA, agonists and competitive antagonists bind?
Where do Benzodiazepines bind?
At which class of receptor (GABAa of GABAb) do barbiturates, neurosteroids, general anaesthetics and ethanol bind?
Which class of y subunits are required for benzodiazepine sensitivity?
Which a subunits are insensitive to benzodiazepines?
What effect do benzodiazepines have if the GABAa receptor contains a a1 subunit?
If the GABAa receptor contains a2 or a3 subunits what effect do benzodiazepines have?
How many subunits does the GABAb receptor have? What are they?
What is the function of each subunit?
Which G protein is the GABAb receptor attached to?
What are the effects of the Gi/o protein activation?
Name a GABAb agonist?
What does Baclofen do?
Which is more important for preventing seizures? GABAa or GABAb?
What two things are possible actions of GABAb antagonists?
Which receptor subtype is responsible for which part of the current?
At which part of the neuron are GABA receptors most useful in relation to blocking the effects of GLUTAMATE receptors?
What is the precursor to glycine?
What are the two different glycine transporters and where are they found?
Where is Glycine a co-agonist?
Which ion passes through Glycine channels?
What is the general structure of a glycine receptor and which subunits can it be composed of?
What are the most likely combinations of subunits?
What is Stychine?
What also potentiates Glycine receptors?
What is HYPEREKPLEXIA
What is it linked to?
