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Dana Alobadily
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Mind Map on Muhammed spleen is palpable, created by Dana Alobadily on 05/08/2017.

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Dana Alobadily
Created by Dana Alobadily over 7 years ago
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Muhammed spleen ispalpableDifferences betweenleukocytosis: increase in the number ofWBCs .' non neoplastic"leukomoid reaction:This is a reactiveand excessive leukocytosis."mimicleukemia"Neutrophilic leukocytosis:(count >7000cells/ mm3)Bacterial infections- Corticosteroids(inhinit margination) -MyocardialinfarctionLymphocytosis: (Absolutecount >4000cells/ mm3Viral infections (infectiousmononucleosis) -Drugs (phynetoin)EosiniophiliaType I hypersensitivity reaction(bronchial asthma- reaction topenicillin)- Helminthic infectionMonocytosisChronic infections : TBWBC counts up to 15 - 100,000/mm3Shift to the left (immature WBCs)Signs of activation Doehle bodies, toxic granulations(Differs the condition from CML)toxic granulationDoehle bodiesNAP scores high (Differs thecondition from CML)MPO negative (Myeloperoxidase) todiffer from CMLHematological neoplasmsHematological History TakingHematology PhysicalExaminationChronic Myeloid Leukemiaphasesconfirming testsFISHPCRpresence of Philadelphiachromosome 22 due totranslocationFusion of 2 genes: BCR (or chromosome22) and ABL1 (on chromosome 9),resulting in BCR-ABL1 fusion geneKaryotypingManagementBone Marrow Biopsy inaccelerated phaseclinical presentationAsymptomaticabdominal fullness due tosplenomegalyweight loss - fatiguetyrosine kinase inhibitorimatinibinhibit TK enzymeHematopoietic stem celltransplantationInvestigationsCBCBlood filmBlood film at 1000X magnificationshows a promyelocyte, aneosinophil, and 3 basophils.Blood film at 400X magnificationdemonstrates leukocytosis with the presenceof precursor cells of the myeloid lineage. Inaddition, basophilia, eosinophilia, andthrombocytosis can be seen.Double click this nodeto edit the textClick and drag this buttonto create a new node