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Dana Alobadily
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more than 1 year ago
Mind Map on Muhammed spleen is palpable, created by Dana Alobadily on 05/08/2017.
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Dana Alobadily
over 7 years ago
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8844181
mind_map
2019-04-29T08:29:22Z
Muhammed spleen is
palpable
Differences between
leukocytosis: increase in the number of
WBCs .' non neoplastic"
leukomoid reaction:This is a reactive
and excessive leukocytosis."mimic
leukemia"
Neutrophilic leukocytosis:
(count >7000cells/ mm3)
Bacterial infections- Corticosteroids
(inhinit margination) -Myocardial
infarction
Lymphocytosis: (Absolute
count >4000cells/ mm3
Viral infections (infectious
mononucleosis) -Drugs (phynetoin)
Eosiniophilia
Type I hypersensitivity reaction
(bronchial asthma- reaction to
penicillin)- Helminthic infection
Monocytosis
Chronic infections : TB
WBC counts up to 15 - 100,000/mm3
Shift to the left (immature WBCs)
Signs of activation Doehle bodies, toxic granulations
(Differs the condition from CML)
toxic granulation
Doehle bodies
NAP scores high (Differs the
condition from CML)
MPO negative (Myeloperoxidase) to
differ from CML
Hematological neoplasms
Hematological History Taking
HematologyPhysical
Examination
Chronic Myeloid Leukemia
phases
confirming tests
FISH
PCR
presence of Philadelphia
chromosome 22 due to
translocation
Fusion of 2 genes: BCR (or chromosome
22) and ABL1 (on chromosome 9),
resulting in BCR-ABL1 fusion gene
Karyotyping
Management
Bone Marrow Biopsy in
accelerated phase
clinical presentation
Asymptomatic
abdominal fullness due to
splenomegaly
weight loss - fatigue
tyrosine kinase inhibitor
imatinib
inhibit TK enzyme
Hematopoietic stem cell
transplantation
Investigations
CBC
Blood film
Blood film at 1000X magnification
shows a promyelocyte, an
eosinophil, and 3 basophils.
Blood film at 400X magnification
demonstrates leukocytosis with the presence
of precursor cells of the myeloid lineage. In
addition, basophilia, eosinophilia, and
thrombocytosis can be seen.
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8844181
mind_map
2019-04-29T08:29:22Z
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