Cognitive Neuroscience: Methods of Study

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Flashcards on Cognitive Neuroscience: Methods of Study, created by Savannah Duggan on 05/10/2017.
Savannah Duggan
Flashcards by Savannah Duggan, updated more than 1 year ago
Savannah Duggan
Created by Savannah Duggan about 7 years ago
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Two part Basic Ontological Postulate 1. All mental processes are the outcome of neural activity 2. And are the outcome of the microscopic interactions and actions of the great neuronal network of the brain - the proper level of analysis of the mind-brain problem
Hebbian Plasticity "fire & wire" When axon of cell A is near enough to excite cell B and repeatedly does so, growth process/metabolic change in A and/or B so A's efficiency is increased as one of the cells firing B
Koch & consicousness consicousness: neuroscience doesn't understand enough about the brain to know how consciousness arises. first step is to determine best neural correlates of consciousness (NCC)
Weaknesses of Neuroscience -Can't study all neurons at once -Can't study all levels at once (behavioural, molecular, cellular, assemblies, networks) -relations between levels often unclear -mostly correlational, experimental limits -mental experince cant be directly obser
Optogenetics real time, restricted to specific neurons, reversible/nonperm uses light to manipuate neuronal activity
Natural Brain lesions stroke, tumour trauma, degenerative disorders (alzheimers, dementia)
Stroke brain stem - fatal in minutes posterior cerebral artery - vision problems left side - language impairment angiography x ray - injected dye hemorrhagic = blood vessel burst ischemic = blood clot blocks artery
Tumours usually from glial cells Can cause damage to surrounding tissue when removed or by pressurizing skull cavity
TBI Traumatic Brain Injury Closed head injury - bruising (coups/ countercoups), changes in white matter Open head - penetration of skull (coups, countercoups, infection, blood flow)
Experimental Lesions Scalpel, aspiration, transection (cut white matter tracts), radio frequency, neurochemical (localize injection), reversible neurochemical (lidocaine, scopolamine), cooling
Artificial Lesions Transcranial Magnetic Stimulation
CAT Scan/CT Scan computed tomography reconstruction of 3d space from compressed 2d xrays cant distringuish white/grey matter, low res, can differentiate skull and ventricles
MRI Magnetic Resonance imaging differentiates between ventricles, white and grey matter, skull
Diffusion Tensor Imaging viewing white matter tracts (connectivity between regions) uses mri scanner to measure density and motion of water in axons measure protons between 2 pulses of energy
EEG electroencephalography surface electrodes on scalp measure summed graded potentials form many thousandsof neurons, reveals features of brain activity: as behaviour changes, patterns and rhythmes, ERPs
ERP event related potential detect which areas are active and order of regional activity
PET Positron Emission Tomography -radioactive molecules injected into blood -detects changes in blood flow by measuring uptake of oxygen and glucose -measures metabolic activity of neurons -can track changes in pH, glucose, amino acids, neurotransmitters, proteins, oxygen
fMRI fucntional magnetic resonance imaging measures amount of oxygen increase (activity = excessive oxygen increase) BOLD signal = Blood Oxygen Level-Dependent, ration of oxygenated to deoxygenated hemoglobin temporally less precise than EEG and ERP
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