Cell Signalling III

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Flashcards on Cell Signalling III, created by J yadonknow on 31/03/2018.
J yadonknow
Flashcards by J yadonknow, updated more than 1 year ago
J yadonknow
Created by J yadonknow almost 7 years ago
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Question Answer
Types of receptors (IGE IRNI) Ion channel-linked (ms) G protein coupled (s-hours) Enzyme-linked (s-hours) Intrinsic Enzyme activity Recruit enzymes from cytoplasm Nuclear Ionotropic ^ hours
Transporters Uniporter - substance 1 direction Symporter - 2 Δ sub. 1 direction Antiporter - 2 Δ sub. Δ directions
Ion channel-linked R Act as gates L-binding induces conf Δ, opening the gate
Pharma modding of ICL Channel blockers (physical block) Channel modulators (bind channel, enhance/inhibit opening.)
GPCRs Most common Trimeric G protein + coupled effector molecule 7 transmem helices
G protein binding site 3rd cytoplasmic loop Cytoplasmic C-terminal tail, sites available for +Pi
G proteins Guanine nucleotide binders
Forms of G proteins Monomeric i.e. Ras Trimeric (alpha,beta,gamma)
Trimeric Only alpha SU can bind Guanine Linked to PCM by lipid chain
GPCR binding (4) 1. Binding of L induces conf. Δ in R 2. + R binds to Gα SU 3. Binding induces conf. Δ in Gα 4. Bound GDP dissociates + is replaced by GTP. 5. Gα dissociates from Gβ/Gγ 6. L dissociated from R, Gα binds and + Effector. 7. Hydrolysis of GTP->GDP causes Gα to dissociate from Eff, re-associate with Gβ/Gγ. SWAPS GTP FOR GDP, DOESN'T CONVERT.
GPCR signal termination by R desensitisation Arrestin binds to +Pi form of GPCR Competes w/ G proteins for binding Promotes R interalisation via Clathrin-mediated endocytosis
Table of trimeric proteins
Learn glycogen metabolism like day before yah
cAMP level regulation using inhibitory hormone An example of GPCR signalling PGE1/Adenosine inhibits adenylyl cyclase GalphaI binds to adenylyl cyclase and inhibits it
Maybe learn AcCh here endothelial cells in BV to bring about smooth muscle relaxation
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