163653
Description
Flashcards by Shannon Grady, updated more than 1 year ago
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Created by Shannon Grady
over 11 years ago
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| Question | Answer |
| CAM | Complementary and Alternative Medicine |
| CNS | Central Nervous System |
| COPD | Chronic Obstructive Pulmonary Disease |
| DSHEA | Dietary Supplement Health and Education Act |
| GLP-1 | Glucagon-like peptide-1 |
| HMG-CoA | 5-hydroxy-3-methylglutaryl-coenzyme A |
| HPLC | High-performance Liquid Chromatography |
| HTS | High-thoroughput Screening |
| LC | Liquid Chromatography |
| M6G | Morphine-6-glucuronide |
| MOA | Memorandum of Agreement |
| MS | Mass Spectrometry |
| NCE | New Chemical Entity |
| NMR | Nuclear Magnetic Resonance |
| PVP | Polyvinylpyrrolidone |
| SCE | Single Chemical Entity |
| SPE | Solid-phase Extraction |
| THC | Tetrahydrocannabinol |
| UNCLOS | United Nations Convention on the Law of the Sea |
| HCl | Hydrochloric Acid |
| IV | Intravenous |
| MW | Molecular Weight |
| NaOH | Sodium Hydroxide |
| PABA | p-aminobenzoic Acid |
| QSAR | Quantitative structure-activity relationship |
| SAR | Structure-activity relationship |
| USP | U.S. Pharmacopeia |
| ADME | Absorption, Distribution, Metabolism, Excretion |
| AP | Absorption Potential |
| ATP | Adenosine 5-Triphosphate |
| ANDA | Abbreviated New Drug Application |
| AUC | Area under the plasma concentration-time curve |
| AUC o | Total area under the plasma concentration-time curve |
| AUMC | Area under the first-moment curve |
| Cl | Clearance |
| Co | Concentration of drug in the organic or oil phase |
| (Cp)max | Plasma peak concentration |
| Cs | Solubility |
| dC | Concentration gradient |
| ER | Extraction Ratio |
| f | Bioavailability |
| F | Absolute bioavailability |
| FDA | U.S.A. Food and Drug Administration |
| Funi | Fraction of un-ionized form |
| IM | Intramuscular |
| K | Elimination Rate Constant |
| Km | The concentration of drug at half the Vmax |
| MAD | Maximum absorbable dose |
| MAT | Mean Absorption Time |
| MKCK | Madin-Darby Canine Kidney |
| MRT | Mean Residence Time |
| NDA | New Drug Application |
| P or logP | Partition coefficient |
| Paq | Aqueous permeability |
| P-gp | P-glycoprotein |
| pKa | the negative logarithm of a dissociation constant, Ka |
| pKw | negative logarithm of dissociation constant of water |
| PSA | polar surface area |
| PSAd | dynamic polar surface area |
| Pw | permeability of a drug in the gut wall |
| Q | blood flow rate |
| SC | subcutaneous |
| SITT | small intestinal transit time |
| SIV | small intestinal volume |
| So | intrinsic solubility |
| t(1/2) | half life |
| t(max) | peak time |
| V | volume of distribution |
| V(1) | volume of the luminal content |
| V(max) | maximum theoretical transfer rate |
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