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| Question | Answer |
| SPECTRUM | the anti-infective activity of a drug is defined by their spectrum. i.e. the set of pathogens that are affected by the antibiotic |
| BACTERICIDES VS BACTERIOSTATIC | bactericides: destruct bacteria bacteriostatic: inhibit bacterial reproduction, without eradicating the bacteria |
| WHAT IS A COMMON PROPERTY TO ALL ANTIBIOTICS? | selective toxicity |
| WHAT ARE THE DIFFERENT TYPES OF ANTIBIOTIC TREATMENTS? | 1.empirical: treatment done without knowing the specific germ causing the infection. 2.specific: treatment chosen after IDing the germ and knowing the antibiogram. |
| HOW IS ANTIBACTERIAL ACTIVITY ACCESSED? | by testing the susceptibility of the microorganism in contact with the antibiotic, using an ANTIBIOGRAM. it is based on diffusion & dilution techniques. |
| MIC | minimum inhibitory concentration |
| MBC | minimum bactericidal concentration |
| MIC (minimum inhibitory concentration) | lowest concentration of antibiotic that is capable of inhibiting the growth of 5 to 10 bacteria in 1 ml of growth medium after 18- 24h of incubation. |
| MBC(minimum bactericidal concentration) | is the lowest concentration that can destroy or kill 5 to 10 bacteria in 1 ml of growth medium after 18-24 h of incubation. |
| HOW IS MIC USED IN PHARMACOLOGY? | MIC is the parameter that classifies a germ sensitivity to an antibiotic in the antibiogram. Bacterial strains can be sensitive or resistant. |
| WHAT CONCENTRATION DOES A THERAPEUTIC ANTI-INFECTIVE NEED TO ACHIEVE? | it needs to achieve an antibiotic tissue concentration which exceeds the MIC. |
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