1726743
Description
Flashcards by sajedashah, updated more than 1 year ago
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Created by sajedashah
about 10 years ago
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| Question | Answer |
| Normocytes | cells of normal size and appearance |
| Anisocytosis | microcystosis/macrocytosis increase in range of red blood cell size associated with many conditions not a type of disorder itself |
| macrocytosis | predominance of large cells associated with: premature release of RBC into circulation and defective cell replication seen in b12 and folate deficiencies |
| microytosis | predominance of small cells associated with: deficiencies of haemabglobin production, reduced availability of iron or RBC damaged during production or in circulation |
| poikilocytosis | irregular cell shapes may have sharp projections e.g. teardrop/helmet/burr cells many causes leads to defective production and damage to RBC |
| spherocytes | do not show a pale centre and often smaller diameter spherical (ball) instead of discoid (flat) formed in peripheral circulation-they leave the BM discoid |
| schistocytes | erythrocyte fragments caused by mechanical damage (haemolysis) |
| normochromic | hypochromasia/polychromasia cells of normal colour-ie pale centre |
| hypochromasia | low Hb content-pale staining of red cells large central area of palllour |
| polychromasia | blue tint in stained red cell caused by immauture RBC containing ER or ribosomal material BM commonly compensates anaemia by premature release of RBC |
| Acanthocytes | spur cell distorted cell with thornlinke projections a-thallasaemia |
| elliptocyte | oval/eliptic cell |
| teardrop cell | teardrop shaped poikilocyte found in myelofibrosis, metastatic marrow infiltration and myelodysplastic syndrome. |
| pencil cells | elliptocyte caused by iron defiecient anaemia and thallasaemia |
| target cell | dark/dense stain in middle, looks like archery target due to shift in erythrocyte:cholesterol equilibrium liver disease/thallasaemia/sickle cell occur sometimes in FEdeficient or post splenectomy |
| Heinz bodies | denatured Hb due to oxidative damage normally all removed by spleen small no seen after splenectomy |
| Howell-Jolly bodies | nuclear remenants normally removed by spleen seen after spenectomy, megoblastic and iron deficient anaemias and sometimes in leukaemia |
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