Acid Base Disorders

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Clinical Chemistry Flashcards on Acid Base Disorders, created by Jessica Taylor on 12/05/2020.
Jessica Taylor
Flashcards by Jessica Taylor, updated more than 1 year ago
Jessica Taylor
Created by Jessica Taylor over 4 years ago
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Question Answer
What are the primary measurements of the blood gas machine pH, pCO2, and pO2
What is pH? The negative log of the Hydrogen concentration -log[H+]
What is pCO2? The partial pressure of carbon dioxide
What is pO2? The partial pressure of oxygen
What are 'Respiratory acid' and 'Respiratory acidosis'? Carbon dioxide is 'respiratory acid' and is the only acid which can be controlled by respiration. When the pCO2 is high, there is 'respiratory acidosis'
What are 'Metabolic acid' and 'Metabolic acidosis'? Metabolic acids are all the body's acids except carbon dioxide - they are not controlled by respiration, hence they have to be neutralised, metabolised, or excreted by the kidney. Metabolic acidosis is a pH which is more acid than appropriate for the pCO2.
What is an acid? A substance that dissociates in water to produce hydronium ions (H3O+) or more commonly (H+)
What is a base? A substance that can accept protons (H+)
What is a buffer? A mixture of a weak acid and its conjugate base that attenuates a change in pH when a strong acid or base is added
Acute Respiratory Acidosis: pH, pCO2, HCO3, Base excess pH: Low pCO2: High HCO3: N Base excess: N
Acute Metabolic Acidosis: pH, pCO2, HCO3, Base excess pH: Low pCO2: N HCO3: low Base excess: low
Acute Respiratory Alkalosis: pH, pCO2, HCO3, Base excess pH: High pCO2: low HCO3: N Base excess: N
Acute Metabolic Alkalosis: pH, pCO2, HCO3, Base excess pH: High pCO2: N HCO3: High Base excess: High
Chronic Respiratory Acidosis: pH, pCO2, HCO3, Base excess pH: N pCO2: High HCO3: High Base excess: High
Chronic Metabolic Acidosis: pH, pCO2, HCO3, Base excess pH: N pCO2: Low HCO3: Low Base excess: Low
Chronic Respiratory Alkalosis: pH, pCO2, HCO3, Base excess pH: N pCO2: Low HCO3: Low Base excess: Low
Chronic Metabolic Alkalosis: pH, pCO2, HCO3, Base excess pH: N pCO2: High HCO3: High Base excess: High
What can be the cause of respiratory acidosis? Rise in CO2 production (fever, sepsis), or failure of ventilation (CNS causes, muscle weakness, increased dead space)
What can be the causes of respiratory alkalosis? Result of hyperventilation or decreased CO2 production
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