2868685
Description
Flashcards by jenny schneider, updated more than 1 year ago
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Created by jenny schneider
over 9 years ago
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| Question | Answer |
| Describe the design of a reservoir system transdermal GTN patch | |
| Describe the design of a matrix system transdermal GTN patch | |
| Why do we administer glyceryl trinitrate tablets (Anginine) sublingually? | 1. rapid absorption into systemic circulation for rapid effect 2. avoid first pass metabolism |
| How should a patient store Anginine (GTN) tablets and why? | 1. in original container and tightly sealed as drug is volatile and it adsorbs to plastic 2. away from body- body temperature will lead to loss of drug (volatility) 3. in a cool place (volatility and decomposition) 4. discard 3months after opening (loss of potency) |
| Why are patients instructed to apply a GTN transdermal patch at 8am and remove at 8pm? | this gives patient a nitrate free period and reduces the development of tolerance to this drug |
| Explain mechanism of action of glyceryl trinitrate | nitric oxide released from nitrate activates guanylate cyclase which converts GTP to cGMP and this activates cGMP-dependent protein kinase which acts to reduce intracellular calcium causing smooth muscle relaxation |
| what is an advantage of GTN as a spray formulation? (nitrolingual spray) | if patient has infrequent angina attacks, this preparation has a much longer shelf-life (2 years) |
| What directions would you give patient on using GTN as a spray | use SL prime the first time used or if not used for 7 days |
| Why do we not give isosorbide mononitrate extended release tablets twice daily (every 12h) | to ensure there is a nitrate free time to reduce development of tolerance |
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