3818168
| Question | Answer |
| CAPTOPRIL 1st orally active ACE inhibitor treat severe essential and renovascular HTN Dysgeusia (taste altering effect causes metallic taste) Cross link with proteins can cause allergies and rashes dont impair sexual or intellectual function no fatigue DOA = 6-12hours 25 -150 mg | |
| ENALAPRIL Prodrug (hydrolyze ester will react with zinc) orally active No thiol group so no taste altering or skin rashes Interindividual differences in conversion to active form DOA 12-24 hours (BID) 5-20 mg | |
| LISINOPRIL Gold standard ACE Inhibitor No Prodrug No Dysgeusia or rashes DOA 24-36 hours QD Active 5-20 mg QD | |
| BENAZEPRIL HCL 1hr onset of action 20-40mg 24 hour DOA | |
| FOSINOPRIL SODIUM Used in patients with reduced renal fnc allows for liver elim 50% elim via bile molecule designed as cascading prodrug 24 hr DOA 20-40mg/day 12 hr half life | |
| QUINAPRIL Resistant to carboxy peptidase prodrug orally active (rapidly esterified) 24 hr DOA | |
| RAMIPRIL Prodrug | |
| MOEXIPRIL 7.5 to 30 mg single or divided dose taken on empty stomach | |
| TRANDOLAPRIL Prodrug | |
| PERINDOPRIL ERBUMINE Prodrug |
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