527453
Description
Flashcards by Mark George, updated more than 1 year ago
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Created by Mark George
almost 11 years ago
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| Question | Answer |
| Lymphomas - malignant tumors of: | Primary lymphoid tissue (thymus) Secondary tissue (lymph nodes, spleen, tonsils) |
| Pathophysiology: | Abnormal chromosomes present in cells of lymph nodes. - Reed-Sternberg cell (RS cells) - not specific to HL Usually arises in a single node Molecular mechanisms causing malignant transformation of cells are unclear - Viruses, genetic factors |
| Clinical Manifestations: | 1st sign: enlarged unilateral painless swelling or mass in neck. CXR shows mediastinal mass Enlargement of cervical, axillary & inguinal lymph nodes common. Fever / sweating / weight loss |
| Diagnosis: | May be difficult due to variety of symptoms. CXR, biopsy, lymphangiography Identify stage once diagnosis made |
| Treatment: | Cure possible regardless of stage (75% success rate). Chemotherapy. Radiation therapy. HIgh dose chemo w/ BM or stem cell transplant (latest Tx option) |
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