539883
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
almost 11 years ago
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| Question | Answer |
| Stages of Latency | III, II, I, 0 |
| EBN A1, 2, 3A, 3B, 3C | Family of transcriptional regulators that influence viral gene transcription |
| LMP1 | Viral mimic of CD40 on B cell surface- important for B cell transformation |
| LMP2 | Effects cell signalling & is believed to inhibit the lytic cycle |
| Proteins expressed in Latency 0 | EBER's and miRNAs (no viral genes) |
| Non Antigenic EBN | EBNA1 |
| Burkitts Lymphoma- Location | Around the malaria belt |
| Burkitts Lymphoma- Age | Children mostly |
| Reason for Location | Immunomodulation of the parasite |
| EBV Conversion | B cells into lymphoblastic cell lines |
| Key Feature of Burkitt's Lymphoma Cases | Chromosomal rearrangement between one of the heavy/light chain enforcers/promoters & the c-myc oncogene |
| Deregulate Gene in Burkitt's Lymphoma | c-Myc |
| Accompanying Mutation | p53 mutation |
| Source of Burkitt's Lymphoma | Cell surface phenotype suggests Germinal Centre B cells, but limited protein production suggests memory B cells |
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