5416797
Description
Flashcards by Flora Bradshaw, updated more than 1 year ago
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Created by Flora Bradshaw
about 8 years ago
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| Question | Answer |
| List the 3 stages of the pain ladder | 1. Non-opioid (e.g aspirin, paracetamol or NSAID) 2. Weak opioid (e.g. codeine) 3. Strong opioid (e.g. morphine) |
| Describe the mode of action of NSAIDs | 1. Inhibition of COX enzymes 2. Prevent AA --> PGH2 --> PGs 3. Prevent inflammation |
| Explain the gastrointestinal side effects of NSAIDs | PG production decrease --> Increased gastric acid production --> Diminished bicarbonate & mucus secretion Acid directly irritates gastric mucosa --> ulceration |
| Explain the renal side effects of NSAIDs | PGs --> Vasodilation of afferent arteriole to maintain high GFR Low PGs --> reduces GFR --> low excretion |
| List 4 other side effects of NSAIDs | 1. Dyspepsia 2. Rashes 3. Hypertension 4. Neuropathy |
| Describe 2 proposed MOAs for paracetamol | 1. Selective COX-3 inhibition (PG inhibitor) 2. Inactivate Trp pain channels in CNS |
| What is a toxic dose of paracetamol? What drug should be given in response? | 10-15g Methionine |
| List the 4 (5) opioid receptors | 1. |
| Describe function |
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