Cancer Gene therapy

Description

Molecular Theraputics Flashcards on Cancer Gene therapy, created by lumen7 on 27/04/2013.
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Flashcards by lumen7, updated more than 1 year ago
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Created by lumen7 over 11 years ago
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Resource summary

Question Answer
There are three categories of genes that may be involved in the causation of cancer Oncogenes; Tumour suppressor genes; Modifying genes
oncogenes growth stimulating genes
Tumour suppressor genes are growth inhibitory genes
Modifying genes broad spectrum of functions, alleles of which can modify the individual predisposition to cancer
suicide gene therapy toxic substances incorporated into DNA during synthesis leading to fragmentation
Oncolytic viruses Viruses that replicate selectively in cancer cells vs normal cells Cancer cells inactivate interferon pathway or mutate tumour suppressor genes, enabling viral replication to proceed When they replicate, they lyse host cells
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