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Created by becki_fernandes
over 11 years ago
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Question | Answer |
where are AB's effective? | tissue fluid |
describe the structure of an antibody | composed of glycoproteins, 2 heavy and 2 light chains linked by disulphide bonds |
describe the constant and variable regions of the molecule | heavy chain is made up of constant region and variable portion at end, which together with end portion of light chain, makes up the antigen binding site |
what are the 3 main functions of antibodies? | neutralisation, opsonisation and complement activation |
name the 5 isotypes | IgD,IgM,IgG,IgA,IgE |
which part of the antibody is different within classes and between classes? | within: variable region (VDJ recombination) between: heavy chain constant |
how does a B cell class switch? | alters which heavy chain gene is used |
where is IgD found and what is its function? | on surface of naive B lymphocytes and acts an as antigen receptor |
what is the role of IgM? | activates complement, good first line of defence |
why is IgG such a good antibody? | can neutralise, activate complement and important for opsonisation |
which is the only antibody to cross the placenta? | IgG |
where is IgA found? | in secretions such as saliva, tears, bronchial secretions, nasal mucosa |
which of the 3 functions is carried out by IgA? | neutralisation |
which cells have a receptor for IgE? | mast cells and eosinophils |
what does IgE trigger in response to parasites or allergic disease? | degranulation of mast cells |
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