6699033
Description
Flashcards by Andrew Street, updated more than 1 year ago
|
Created by Andrew Street
about 8 years ago
|
|
| Question | Answer |
| Give eg's of & indications for genitourinary antimuscarinics. | eg's: oxybutynin, tolterodine, solifenacin Indications: • Overactive bladder - reduces urinary frequency, urgency, & urge incontinence. 1st line pharmacological Rx if bladder training is ineffective. |
| MOA of genitourinary antimuscarinics. | Antimuscarinic drugs bind to muscarinic receptors, where they act as a competitive inhibitor of acetylcholine. Contraction of the smooth muscle of the bladder is under parasympathetic control. Blocking muscarinic receptors therefore promotes bladder relaxation, ^bladder capacity. In pt's with overactive bladder, this may reduce urinary frequency, urgency & urge incontinence. Antimuscarinics useful in treating overactive bladder tend to be relatively selective for the M3 receptor, which is the main muscarinic receptor subtype in the bladder. |
| SE's of genitourinary antimuscarinics. | • Dry mouth • Tachycardia • Constipation • Blurred vision |
| CI's, cautions, & important interactions of genitourinary antimuscarinics. | CI's: • UTI Cautions: • CNS SE's can be especially problematic in the elderly & those with dementia • Pt's susceptible to angle-closure glaucoma • Pt's at risk of arrhythmias • Pt's at risk of urinary retention Important interactions: Adverse effects are more pronounced when combined with other drugs that have antimuscarinic effects, such as tricyclic antidepressants. |
Want to create your own Flashcards for free with GoConqr? Learn more.