6838128
Description
Flashcards by Dan McArthur, updated more than 1 year ago
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Created by Dan McArthur
about 8 years ago
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| Question | Answer |
| Nifedipine | - Blocks Calcium Channels - Reduces blood vessel constriciton - Reduces Blood Pressure |
| Fluoxitine | - Blocks 5-HT reuptake - Prolongs effects of 5-HT |
| Aspirin | - Inhibits Cyclo-Oxygenase (COX) - Reduces inflammatory response - Binds covalently |
| L-Dopa | - Increases synthesis of Dopamine |
| Morphine | - Activates opioid receptors for pain relief |
| Naloxone | - Opioid receptor antagonist - Used for heroin overdoses |
| Ionotropic Receptors | Agonists bind and directly regulate the opening of the ion channel |
| Metabotropic Receptors | Agonist binding causes series of intracellular events to indirectly produce effects |
| Nicotinic Receptors | Located on skeletal muscle, and at the preganglionic junction of Para and Sympa neurons. Ach binds and causes Sodium Channels to open |
| Kinase-Linked Receptors | Agonist binding causes the activation of the cytoplasmic domain that has Kinase Activity |
| Cytoplasmic Receptors | Receptors for lipid-soluble agonists Agonist-receptor binds and enters the nucleus Regulates gene expression e.g. Glucocorticoid Receptors |
| G-Protein Coupled Receptors | Largest receptor family Linked to an effector protein by a G-protein e.g. Muscarinic Receptors |
| GPCR: Adenylate Cyclase | Produces cAMP which has activation activity in the cell |
| GPCR: Phospholipase C | Catalyzes PIP2 into Inositol Triphosphate and DAG Increases intracellular Calcium levels in the cell Used by Beta Adrenoceptors and Alpha1 |
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