7349156
Description
Flashcards by Andrew Street, updated more than 1 year ago
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Created by Andrew Street
almost 8 years ago
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| Question | Answer |
| Indications for gabapentin & pregabalin. | • Focal epilepsies - usually as an add-on Rx when other antiepileptic drugs aren't adequate • Neuropathic P • Migraine prophylaxis (gabapentin) • GAD (pregabalin) |
| MOA of gabapentin & pregabalin. | From a structural point of view, gabapentin is closely related to γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain. However, its MOA, although not completely understood, appears largely unrelated to GABA. It binds with voltage-sensitive calcium (Ca2+) channels, where it presumably prevents inflow of Ca2+ &, in so doing, inhibits neurotransmitter release. This interferes with synaptic transmission & reduces neuronal excitability. Pregabalin is a structural analogue of gabapentin that probably has a similar mechanism of action. |
| SE's of gabapentin & pregabalin. | • Drowsiness • Dizziness • Ataxia |
| CI's, cautions, & important interactions of gabapentin & pregabalin. | CI's: • None Cautions: • Renal impairment (reduce dose) Important interactions: The sedative effects of gabapentin & pregabalin may be enhanced when combined with other sedating drugs (eg benzodiazepines). Other than this, gabapentin & pregabalin are notable in having relatively few drug interactions – in stark contrast to most other antiepileptic drugs. This makes them particularly useful where combination regimens are considered necessary. |
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