8293260
Description
Flashcards by Amelia Claire, updated more than 1 year ago
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Created by Amelia Claire
over 7 years ago
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| Question | Answer |
| Unique characteristic of sympathetic nervous system is that: | It uses both noradrenaline and acetylcholine as neurotransmitters |
| Acetylcholine is synthesised from: | Acetyl-CoA and choline |
| Which cholinergic neurone will have voltage-gated calcium channels at the synapse? | Pre-synaptic neuron |
| What is the main function of Acetylcholine esterase? | To degrade acetylcholine – end product is acetic acid and choline |
| Why is atropine an antidote for nerve | It has anticholinergic effects |
| What is the function of calcium in presynaptic nerve at the synapse? | To participate in neurotransmitter release from presynaptic nerves (acetylcholine) |
| What happens in stage 3 at a cholinergic synapse? | Acetylcholine diffuses across the synaptic cleft and binds to receptors at the post synaptic nerve |
| Which neurotransmitter is used at the neuromuscular junction? | Acetylcholine |
| Indirect-acting cholinergic drugs are: | cholinergic drugs: Agonists of acetylcholine receptors (to PNS) |
| Neostigmine is: | Reversible acetylcholine esterase inhibitor |
| Which of these is NOT a cholinergic drug effect? 1. Sweating inhibition – drying effect 2. Lacrimation 3. Urinary incontinence 4. Diarrhoea | 1 - sweating. cholinergic drugs have a 'wetting' effect |
| Pancuronium is: | Non-depolarizing neuromuscular blocker [competitive blocker] |
| Parasympathomimetics are drugs that: | acts like acetylcholine; activates parasympathetic nervous transmission |
| Opening of the eye pupil could be achieved by: | Parasympatholytics and Sympathomimetics |
| Organophosphates are potent: | indirect acting parasympathomimetics |
| Myasthenia gravis is caused by | Inactivation of nicotinic receptors |
| Hyoscine is most similar to: Neostigmine Atropine Pancuronium (muscle relaxant -> anti cholinergic -> targets neuromuscular junction) | anticholinergic Atropine – targets muscularanic targets |
| Overdose of neostigmine could be treated with: 1. Pilocarpine 2. Neostigmine 3. Atropine 4. Pancuronium | Atropine |
| Major suxamethonium effect is: | Muscle relaxation |
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