Cell Biology : Glycolysis and Krebs Cycle

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Cell Biology Flashcards on Cell Biology : Glycolysis and Krebs Cycle, created by savaniprachi on 30/05/2014.
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Flashcards by savaniprachi, updated more than 1 year ago
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Created by savaniprachi over 10 years ago
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Question Answer
What are the regulatory points in Glycolysis? Steps 1, 3 and 10. - hexokinase - phosphofructokinase - pyruvate kinase
What is hexokinase regulated by? Glucose-6-phosphate
What is PFK-1 regulated by? Inhibited by ATP. Action reversed by AMP
What is pyruvate kinase regulated by? Inhibited by ATP and Acetyl-coA Activated by fructose-1,6 bisphosphate (step 4)
What happens in tarui disease? The cells cannot convert fructose 6-phosphate to fructose 1,6-bisphosphate (step 3) therefore there is a build up of glycogen in muscles.
What happens if there is a deficiency of pyruvate kinase? Less ATP production, RBC short half life and lyse easily
Under anaerobic conditions, what is pyruvate converted to? Lactate
What activates the PDH complex? AMP, NAD+, coA
What inhibits PDH activity? ATP, NADH, Acetyl CoA
Do high concentrations of the end products (ATP and NADH) stimulate the cycle? No they inhibit it. Substrates like NAD+ and ADP stimulate the cycle
How does sodium fluoroacetate affect the Krebs cycle? It inhibits formation of isocitrate therefore causing a build of of citric acid
What are some of the effects of acute exposure and serious poisoning of sodium fluoroacetate? Nausea vomiting and diarrhoea. Serious poisoning can cause seizures, comas, respiratory depression among other cardiac symptoms
What is Beri Beri and how does it affect the Krebs cycle? Vitamin B1 (thiamine) deficiency. Thiamine phosphate is required as a part of pyruvate dehydrogenase and α-ketoglutarate dehydrogenase. It results to high levels of pyruvate and α-ketoglutarate in blood.
What type of symptoms is Beri Beri characterised by? Neurological and cardiac
What kind of symptoms would you expect from Beri Beri? Limb pain, weak muscles, distorted skin sensation. May be enlargement of heart with low cardiac output
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