11240004
Description
Mind Map by Menna Emam, updated more than 1 year ago
|
Created by Menna Emam
about 7 years ago
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|
Quit Smoking
- Ali was later found out to have
- Bronchogenic Carcinoma ( lung cancer)
- classified into
- Neuroendocrine cells
- Small Cell Lung Cancer
(SCLC)
- Small Cell Lung Cancer
(SCLC)
- Epithelial cells
- Non-small Cell Lung Cancer
(NSCLC)
- includes
- Squamous cell carcinoma
- Large cell carcinoma
- Adenocarcinoma
- Histology
- Gland-forming adenocarcinoma, which on IHC
will show TTF-1 positivity which is se- en in
majority of pulmonary adenocarcinomas
- Gland-forming adenocarcinoma, which on IHC
will show TTF-1 positivity which is se- en in
majority of pulmonary adenocarcinomas
- Histology
- Histology
- Composed of solid groups of large anaplastic
malignant cells. Cells typically have large nu- clei,
prominent nucleoli, and a moderate amo- unt of
cytoplasm.
- Composed of solid groups of large anaplastic
malignant cells. Cells typically have large nu- clei,
prominent nucleoli, and a moderate amo- unt of
cytoplasm.
- Adenocarcinoma
- Histology
- Well differentiated squamous cell carcinoma
showing nests of squ- amous cells with central
areas of keratinization
- Desmosomes
- Desmosomes
- Desmosomes
- squamous cell nests (pearls)
with central keratinization
- squamous cell nests (pearls)
with central keratinization
- Desmosomes
- Well differentiated squamous cell carcinoma
showing nests of squ- amous cells with central
areas of keratinization
- X-ray
- left lung opacity (central lung
mass)
- left lung opacity (central lung
mass)
- Gross
- Large cell carcinoma
- Squamous cell carcinoma
- includes
- Non-small Cell Lung Cancer
(NSCLC)
- Neuroendocrine cells
- Treatment
- The commonest used chemotherapy
combination for small cell is:
- Cisplatin and etoposide
- CAV (cyclophosphamide, doxorubicin, vincristine)
- GemCarbo (gemcitabine and carboplatin)
- For relapsed
disease:
- ACE (doxorubicin, cyclop- hosphamide
and etoposide)
- ACE (doxorubicin, cyclop- hosphamide
and etoposide)
- Topotecan:
- for people whose SCLC has relapsed
after treatment, but only if they are
not able to have doxorubicin
- for people whose SCLC has relapsed
after treatment, but only if they are
not able to have doxorubicin
- Cisplatin and etoposide
- Chemotherapy for non-small cell lung cancer (NSCLC)
- NSCLC is not as sensitive to chemotherapy as
SCLC.
- Surgery or radiotherapy are the main treatments.
- Chemotherapy may be given before or after
surgery or radiotherapy
- Chemotherapy with either:
- Gemcitabine, paclitaxel, docetaxel or vinorelbine
- Together with a platinum drug (carboplatin or cisplatin) should be
the first choice for people with advanced NSCLC stage 3 and 4
- Gemcitabine, paclitaxel, docetaxel or vinorelbine
- Chemotherapy with either:
- Chemotherapy may be given before or after
surgery or radiotherapy
- Surgery or radiotherapy are the main treatments.
- NSCLC is not as sensitive to chemotherapy as
SCLC.
- The commonest used chemotherapy
combination for small cell is:
- Multistep carcinogenesis
- Smoking
- Environmental exposure
- Genetics
- Smoking
- Local Effects
- Cough (75%)
- Weight loss
(40%)
- Chest pain (40%)
- Dyspnea (20%)
- Others :
Hemoptysis,
Loss of appetite,
Obstructive
symptoms
- Others :
Hemoptysis,
Loss of appetite,
Obstructive
symptoms
- Dyspnea (20%)
- Chest pain (40%)
- Weight loss
(40%)
- Systemic effects
- Paraneoplastic
Syndromes:
- Cushing's syndrome
(ACTH)
- Inappropriate ADH secretion
- Hypercalcemia (PTH)
- Acromegaly (GH)
- Lambert-Eaton
mysthenic syndrome
- Peripheral neuropathy
(sensory)
- Hematologic
abnormalities (leukemoid
reaction, DIC, migratory
thrombophlebitis)
- Hypertrophic pulmonary
osteoarthropathy
(clubbing of the fingers)
- Hypertrophic pulmonary
osteoarthropathy
(clubbing of the fingers)
- Hematologic
abnormalities (leukemoid
reaction, DIC, migratory
thrombophlebitis)
- Peripheral neuropathy
(sensory)
- Lambert-Eaton
mysthenic syndrome
- Acromegaly (GH)
- Hypercalcemia (PTH)
- Inappropriate ADH secretion
- Cushing's syndrome
(ACTH)
- Paraneoplastic
Syndromes:
- Etiology
- Diagnosis
- Medical History
- Physical
Examination
- Chest x-ray
- CT scan
- Low dose spiral CT
- PET scan
- Sputum cytology
- Guided needle
biopsy
- Thoracoscopy
- Bronchoscopy
- Bronchoscopy is a test to view the airways and diagnose lung disease. It may also
be used during the treatment of some lung conditions.
- Bronchoscopy is a test to view the airways and diagnose lung disease. It may also
be used during the treatment of some lung conditions.
- Bronchoscopy
- Thoracoscopy
- Guided needle
biopsy
- Sputum cytology
- PET scan
- Low dose spiral CT
- CT scan
- Chest x-ray
- Physical
Examination
- Medical History
- classified into
- Bronchogenic Carcinoma ( lung cancer)
- Ali's Chief complain was
- Hemoptysis
- definition
- The expectoration of blood or
bloodstained sputum. With massive
hemoptysis the main priorities are to
secure the airway and initiate
emergency resuscit- ative measures
before establishing a diagnosis.
- The expectoration of blood or
bloodstained sputum. With massive
hemoptysis the main priorities are to
secure the airway and initiate
emergency resuscit- ative measures
before establishing a diagnosis.
- definition
- Percussion showed
- Pleural effusion
- Abnormal values
- Normal contents of
pleural fluid
- Abnormal values
- Pleural effusion
- Hemoptysis
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