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11953541
Neuromuscular Junction
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User has deleted their subject information Mind Map on Neuromuscular Junction, created by Deleted user on 21/01/2018.
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Plymouth Med
over 6 years ago
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Plymouth Med
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Resource summary
Neuromuscular Junction
Terminal Axon
Motor End Plate of Muscle Fiber
4) Receptors open up ligand-gated cation channels
5) Depolarization of sarcolemma membrane via t-tubules
Sodium ions enter muscle fiber
Potassium ions leave muscle fiber
goes from -70 mv--> +40 mv
6) Action potential fired along length of the muscle fiber
travels length of the myotube
Muscle fiber/myotube
Sarc. Reticulum
Storage of calcium ions
Resting muscle = HIGH [Calcium]
ATP-fueled CA2+ pumps/channels
Sarcoplasm (membrane)
Myofibril
Made of 2 myofilaments
Cross Bridge Interaction
Actin
Has myosin binding sites
Thick strand
Myosin
Double Headed, Thin strand
covered by Tropomyosin
Calcium binding sites
Myosin heads activated via ATP
ATP from Creatine Phosphate
most abundant source of ATP for skeletal muscles
Enzyme Creatine Kinase
Break phosphates into ATP
Build ATP back up together
Break it into ADP and P
Muscle chance to relax until ATP formed again
t-tub
7) take action potential deep into the individual muscle cells
8) Causes sarcoplasmic Reticulum to release calcium into sarcoplasm
DHP receptors cause release of calcium
DHP--> voltage-dep calcium channel
9) Calcium rushes off and binds to tropomyosin
Conformational Change
10) Tropomyosin moves away
11) Actin binds to Myosin
Actin pulls itself along= MUSCLE CONTRACTION
Contraction END: when Calcium ions actively transported back to sarcoplasmic reticulum
Neuron
1) Action Potential arrives From Neuron
2) CA 2+ ions diffuse into the dendrite
go into presynaptic end
via open voltage-gated calcium channels
Calcium influx
synaptic vesicles ready to fire AcH
AcH released into the synaptic cleft
released via exocytosis
3)Diffuses across and binds to receptors on motor end plate
presynaptic AcH binding--> + feedback loop
preps more Ach release
sustain/more muscle contraction
AcH removal
Reuptake
Diffuses back across cleft
Broke down
Acetylcholinesterase
Acetyl Acid
Choline
All muscle types use calcium and ATP for contraction
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