Copy and Edit

Innate Immunity :)

Description

User has deleted their subject information Mind Map on Innate Immunity :), created by Deleted user on 23/01/2018.
Deleted user
Mind Map by Deleted user, updated more than 1 year ago More Less
Plymouth Med
Created by Plymouth Med almost 7 years ago
Plymouth Med
Copied by Plymouth Med almost 7 years ago
8
0
0

Resource summary

Innate Immunity :)
  1. Physical Barriers
    1. Skin
      1. Mucosa
        1. Acidic pH
          1. Tears (antiseptic)
            1. Cilia
              1. Enzymes
                1. Microcidal molecules
                2. First Line Defense
                  1. Normal Microbial Flora
                    1. Serum Proteins
                      1. Complement (Cascade)
                        1. Classical
                          1. Antigen-Antibody
                            1. More common one
                          2. Alternative
                            1. Spontaneous
                              1. Ex: Bacterial Toxins
                              2. all 3 lead to C3 convertsase
                                1. Cleaves
                                  1. C3a
                                    1. anaphalotoxin
                                      1. Mast cell degranulation
                                        1. Release Histamine
                                          1. Increased Vasodilation
                                          2. Release Bradykinin
                                            1. Increased Vascular Permeability
                                              1. Rolling Adhesion of Leukocytes
                                                        1. Vasodilation
                                                            1. blood flow slows down
                                                              1. allows monocytes to roll along epithelial edges
                                                      2. S
                                                        1. S
                                                          1. S
                                                            1. S
                                                          2. Selectins
                                                            1. Binds to glycoproteins on leukocyte to slow it down
                                                            2. I
                                                              1. I
                                                                1. I
                                                                  1. I
                                                                2. Integrins
                                                                  1. Activated by neutrophil activation
                                                                    1. Stops monocyte
                                                                  2. L
                                                                    1. L
                                                                      1. L
                                                                        1. L
                                                                          1. L
                                                                            1. Diapedesis
                                                                              1. macrophage goes into the epithelium to site of injury
                                                                      2. Leukocyte
                                                                    2. epithelium
                                                                      1. IL-1
                                                                        1. TNF alpha
                                                                            2. Chemokines increases adhesiveness of epithelial cells
                                                                      2. Pathogen
                                                                        1. Break in Epithelium
                                                                          1. IL-8 released
                                                                            1. chemotaxis
                                                                              1. leukocytes come over
                                                                                1. 1. Neutrophils
                                                                                  1. 2. Antigen Presenting Cells
                                                                                    1. Dendritic Cells
                                                                                      1. Macrophages
                                                                                        1. Go off to lymph node to present antigen
                                                                                          1. Start of Acquired Immunity
                                                                                      2. 3. Natural Killer Cells
                                                                                        1. Detects clumps of bacteria
                                                                                          1. Clumping due to antibodies
                                                                                  2. Prostaglandins released
                                                                          2. Promotes Inflammation
                                                                            1. Loss of functionality
                                                                              1. Swelling
                                                                                1. Pain
                                                                                  1. Heat
                                                                                  2. Redness
                                                                          3. C3b
                                                                            1. Leads to cleaving of C5
                                                                              1. C5a
                                                                                1. C5b
                                                                                  1. C5b-9
                                                                                    1. Membrane Attack Complex (MAC)
                                                                                2. Complement
                                                                                  1. Opsonin
                                                                                    1. Coats bacteria
                                                                                      1. Enhances chemotaxis and phagocytosis
                                                                          4. Mannase-Binding Lectin
                                                                            1. Interact with bacteria directly
                                                                        Show full summary Hide full summary

                                                                        Want to create your own Mind Maps for free with GoConqr? Learn more.

                                                                        Similar

                                                                        KEE1
                                                                        harrym
                                                                        HSC Economics
                                                                        lydia le
                                                                        Sailmaker
                                                                        julieshirlaw
                                                                        Graphics Key Words
                                                                        Mrs.Barnes
                                                                        GCSE Chemistry C2 topic notes
                                                                        imogen.shiels
                                                                        Food Technology - KEY TERMS
                                                                        Dani Whitrick
                                                                        Science Additional B3 - Animal and Plant Cells Flashcards
                                                                        Stirling v
                                                                        GCSE geography natural environment
                                                                        Archie Horwood
                                                                        NSI Test First day
                                                                        brahim matrix
                                                                        Power and Conflict Poetry
                                                                        Charlotte Woodward
                                                                        Clinical Pathoanatomy MCQs (Q 151-250)
                                                                        Ore iyanda
                                                                        Browse Library