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11976586
Innate Immunity :)
Description
User has deleted their subject information Mind Map on Innate Immunity :), created by Deleted user on 23/01/2018.
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Mind Map by Deleted user, updated more than 1 year ago
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Created by
Plymouth Med
over 6 years ago
Copied by
Plymouth Med
over 6 years ago
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Resource summary
Innate Immunity :)
Physical Barriers
Skin
Mucosa
Acidic pH
Tears (antiseptic)
Cilia
Enzymes
Microcidal molecules
First Line Defense
Normal Microbial Flora
Serum Proteins
Complement (Cascade)
Classical
Antigen-Antibody
More common one
Alternative
Spontaneous
Ex: Bacterial Toxins
all 3 lead to C3 convertsase
Cleaves
C3a
anaphalotoxin
Mast cell degranulation
Release Histamine
Increased Vasodilation
Release Bradykinin
Increased Vascular Permeability
Rolling Adhesion of Leukocytes
Vasodilation
blood flow slows down
allows monocytes to roll along epithelial edges
S
S
S
S
Selectins
Binds to glycoproteins on leukocyte to slow it down
I
I
I
I
Integrins
Activated by neutrophil activation
Stops monocyte
L
L
L
L
L
Diapedesis
macrophage goes into the epithelium to site of injury
Leukocyte
epithelium
IL-1
TNF alpha
Chemokines increases adhesiveness of epithelial cells
Pathogen
Break in Epithelium
IL-8 released
chemotaxis
leukocytes come over
1. Neutrophils
2. Antigen Presenting Cells
Dendritic Cells
Macrophages
Go off to lymph node to present antigen
Start of Acquired Immunity
3. Natural Killer Cells
Detects clumps of bacteria
Clumping due to antibodies
Prostaglandins released
Promotes Inflammation
Loss of functionality
Swelling
Pain
Heat
Redness
C3b
Leads to cleaving of C5
C5a
C5b
C5b-9
Membrane Attack Complex (MAC)
Complement
Opsonin
Coats bacteria
Enhances chemotaxis and phagocytosis
Mannase-Binding Lectin
Interact with bacteria directly
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