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13542415
Dioxina
Description
Mind Map on Dioxina, created by celena barahona on 02/05/2018.
Mind Map by
celena barahona
, updated more than 1 year ago
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Created by
celena barahona
about 6 years ago
7
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Resource summary
Dioxina
TCDD
Se une al receptor AhR
Codifica CYP450
Aumenta la transcripción de genes
Inactiva la producción de
Glutatión -s-tranferasa aldehído deshidrogenasa glucoronil transferasa
Aumenta la concentración de algunas sustancias tóxicas y aumenta estrés oxidativo
Aumento de sustancias carcinogenasas
Cáncer
Aumenta la codificación de
1A1, 1A2, 1B1
Aril hidroxilasa
Hidróxila HAP
HAP-hidroxilados interaccionan sobre ADN
Mutación a protooncogenes como myc, supresor P53
Desarrollo de cáncer
Disminuye la síntesis de progesterona y aumenta el colesterol inactivo
Aumento de los RDS
Aumento de la proliferación celular
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