Side Effects: HTN,
tachy, arrhythmias,
myocardial ischemia
Selective beta 1 agonist - improves CO (esp if HR
and SVR are high); dose dependent increases in CO
without marked increases in HR or BP
Phosphodiesterase inhibitors: lead to
increased c-AMP --> improved uptake,
storage and release of Ca from SR
Amrinone
Indications: short term CHF tx
Side effects:
thrombocytopenia,
tachyphylaxis, hypoK, GI
effects
Increases cardiac index while decreasing SVR and
cardiac filling pressures. HR unchanged/increases
very slightly. DOES NOT increase myocardial
oxygen consumption. Also enhances A-V
conduction; patients with atrial arrhythmias should
be pretreated with digitalis
Milrinone - enhanced vasodilatory properties
compared to amrinone; causes greater decreases
in LV pressure and BP than amrinone
Chronotropes - heart rate
Atropine - 0.5mg q2min, total 2mg
Isoproterenol: B1 + B2 - useful in 3rd degree
block and EMD. PROBLEM: may decrease SVR
and MAP while also increasing HR, contractility
and myocardial O2 consumption