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Dysbiosis

Dysbiosis is the shift in balance of normal microflora (type and quantity, metabolic activity and distribution) in the large intestine, resulting in a microbata which produces harmful effects
Small intestine bacterial overgrowth (SIBO)
Causes
1. Stress
2. Poor diet
3. Decreased digestive secretions
4. Antibiotics
5. Excessive alcohol
6. Altered bowel motility
7. Immune suppression
Symptoms
1. Local symptoms
  1. Indigestion
  2. bloating
  3. nausea
  4. diarrhea/constipation
2. Associated with diseases
  1. Immune disregulation
  2. inflammation
  3. metabolic disturbances
  4. Systemic
    1. Autoimmune
      1. Rheumatoid arthritis
      2. Ankalising spondilitis
      3. Allergies
      4. UTI's
      5. Thrush
3. GIT
  1. Irritable bowel syndrome
  2. inflammatory bowel disease
  3. enteric infections
Leads to:
1. Increased intestinal permeability, pathogens adhere to epithelial lining and damage tight junctions
2. Inflammation: pathogens induce epithelial cells to secrete inflammatory cytokines, adhesion molecules, and major hitocompatibility complex class II molecules, stimulates immune cells eg neutrophils, monocytes, lymphocytes and eosinophils

Dysbiosis

	Created by carlymerlo over 11 years ago