1577969
Description
Mind Map by Syar Amsyar, updated more than 1 year ago
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Created by Syar Amsyar
almost 10 years ago
|
|
Acute Inflammation &
Immune Response
- Innate Immune
Response
- Recruitment of
immune cells
- to infection
sites
- chemokines
- cytokines
- chemokines
- to infection
sites
- Activation of
complement cascade
- identify
bacteria
- activate
cells
- promote
clearance
- identify
bacteria
- identify/remove
foreign substance
- Immediate
- Innate
Defenses
- Anatomic
Barriers
- Physiological
Barriers
- Phagocytic Cells
- Inflammation
- Anatomic
Barriers
- Recruitment of
immune cells
- Acquired Immune
Response
- Recognition of
specific antigens
- specific responses
maximized
- eliminate specfic
- pathogens
- infected
cells
- pathogens
- eliminate specfic
- Development of
immunological memory
- Slow response
(3-5 days)
- Share signal
molecules
- Depend largely on
WBC activity
- Depend largely on
WBC activity
- 4 main characteristics
- Specificity
- diversity
- self/non-self
recognition
- immunologic
memory
- Specificity
- Recognition of
specific antigens
- Acute
- immediate
response
- to tissue injury
- to tissue injury
- Symptoms
- Rubor (redness)
- Vasodilation of
blood vessels
- Vasodilation of
blood vessels
- Tumor (swelling)
- Increased permeability
of capillaries
- Clotting in
interstitial spaces
- migration of
phagocytic cells
- Increased permeability
of capillaries
- Calore (tissue
heating)
- Vasodilation
- Vasodilation
- Dolore
(pain)
- release of
kinins
- from blood
clotting cascade
- from blood
clotting cascade
- release of
kinins
- Rubor (redness)
- immediate
response
- Leukocytes
- Granulocytes
- Neutrophils
- Extravasation
- Rolling
- Activation
- Adhesion
- Locomotion
- Protusion
- Transmigration
- migrate to area
of inflammation
- migrate to area
of inflammation
- penetrate
endothelial layer
- Transmigration
- Protusion
- bind to vascular
endothelium
- Locomotion
- Adhesion
- Activation
- Rolling
- Actions
- Phagocytosis
- Respiratory
burst
- rapid release of
reactive O and N
- rapid release of
reactive O and N
- secrete chemical
mediators
- cytokines
- IL-8
- attracts other
neutrophils
- attracts other
neutrophils
- MIP-1a
- attracts
monocytes
- attracts
monocytes
- IL-8
- cytokines
- Phagocytosis
- first to
arrive
- Extravasation
- Eosinophils
- respond to
chemoattractants
- small phagocytic
capability
- attach to &
destroy parasites
- respond to
chemoattractants
- Basophils
- induced to release
- heparin, histamine,
bradykinin, serotonin
- heparin, histamine,
bradykinin, serotonin
- large role in
allergic reactions
- induced to release
- Neutrophils
- Agranulocytes
- Monocytes
- 5-6 hrs after
neutrophil arrival
- tissue
macrophages
- maturation
- swelling of
cells
- formation of
lysosomes
- in large quantities
- in large quantities
- Macrophages
- Phagocytosis
- engulf more
than neutrophils
- remain
longer
- engulf more
than neutrophils
- Secretion of
chemical mediators
- IL-1
- IL-6
- tumor necrosis
factor (TNF)
- IL-1
- Role as antigen
presenting cells (APCs)
- direct connection
b/w
- innate
- acquired
- innate
- direct connection
b/w
- Phagocytosis
- swelling of
cells
- maturation
- tissue
macrophages
- 5-6 hrs after
neutrophil arrival
- Lymphocytes
- T cells
- B cells
- Acquired Immunity
- T cells
- Monocytes
- Granulocytes
- Non -specific
Chemical Defences
- histamine
- speeds release
of agents
- initiates
inflammatory
response
- speeds release
of agents
- Cytokines
- signalling
molecules
- cell
communication
- cell
communication
- interleukins
- involved in regulation
of immune system
- cell mediated immunity
- cell mediated immunity
- involved in regulation
of immune system
- inteferons
- cell-signalling
protein
- anti-viral
agents
- cell-signalling
protein
- signalling
molecules
- Complement
system
- biochemical
cascade
- speeds up
phagocytosis
- speeds up
phagocytosis
- kills bacteria
via lysis
- biochemical
cascade
- histamine
- Termination
- why?
- physiological
changes
- detrimental to
tissue function
- detrimental to
tissue function
- physiological
changes
- how?
- chemical
mediators
- provide system
checks & balances
- ensure
localized effects
- ensure
localized effects
- provide system
checks & balances
- production
of substances
- limits
inflammatory
response
- limits
inflammatory
response
- chemical
mediators
- why?
- Assays
- In Vitro
- leukocyte assay
- test cell activation
- use neutrophils/
macrophages
- use neutrophils/
macrophages
- cell adhesion & spreading
- cell death
- cell migration
- cytokine release
- cell surface marker expression
- flow
cytometry
- flow
cytometry
- test cell activation
- leukocyte assay
- Others
- response of
endothelial cells
- testing for
up-regulation
- cell surface
receptors
- analysed
using FACS/FC
- analysed
using FACS/FC
- cell surface
receptors
- testing for
up-regulation
- model systems for tissue
engineering constructs
- monitor pdtn of
cytokines via ELISA
- monitor pdtn of
cytokines via ELISA
- response of
endothelial cells
- In Vitro
Media attachments
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