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2044716
Antiphospholipid syndrome
Description
Mind Map on Antiphospholipid syndrome, created by Laura Smitherman on 16/02/2015.
Mind Map by
Laura Smitherman
, updated more than 1 year ago
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Created by
Laura Smitherman
over 9 years ago
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Resource summary
Antiphospholipid syndrome
Cause
autoimmune
?antiphospholipid antibodies
lupus anticoagulant
anti-cardiolipin
anti-β2-glycoprotein-I
complement and platelet activation
genetic
unknown
presentation
hypercoagulable state
venous
DVT
PE
arterial
stroke
pregnancy complications
stillbirth
miscarriage
preterm delivery
severe pre-eclampsia
Livedo reticularis
haemolytic anaemia
thrombocytopenia
Types
Primary
HLA-DR7
Secondary
risk factors
associated with other autoimmune diseases e.g. SLE, RA
HLA-B8, HLA-DR2, HLA-DR3
ethnicity
most common in young fertile women
Management
Lifestyle to reduce cardiovascular risks
Thrombosis risk
Acute
Heparin
Long term
Warfarin (INR 2-3) or antiplatelet
In pregnancy
LMWH + aspirin
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