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Antiphospholipid syndrome

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Mind Map on Antiphospholipid syndrome, created by Laura Smitherman on 16/02/2015.
Laura Smitherman
Mind Map by Laura Smitherman, updated more than 1 year ago
Laura Smitherman
Created by Laura Smitherman over 9 years ago
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Resource summary

Antiphospholipid syndrome
  1. Cause
    1. autoimmune
      1. ?antiphospholipid antibodies
        1. lupus anticoagulant
          1. anti-cardiolipin
            1. anti-β2-glycoprotein-I
            2. complement and platelet activation
            3. genetic
              1. unknown
              2. presentation
                1. hypercoagulable state
                  1. venous
                    1. DVT
                      1. PE
                      2. arterial
                        1. stroke
                      3. pregnancy complications
                        1. stillbirth
                          1. miscarriage
                            1. preterm delivery
                              1. severe pre-eclampsia
                              2. Livedo reticularis
                                1. haemolytic anaemia
                                  1. thrombocytopenia
                                  2. Types
                                    1. Primary
                                      1. HLA-DR7
                                      2. Secondary
                                        1. risk factors
                                          1. associated with other autoimmune diseases e.g. SLE, RA
                                            1. HLA-B8, HLA-DR2, HLA-DR3
                                              1. ethnicity
                                                1. most common in young fertile women
                                            2. Management
                                              1. Lifestyle to reduce cardiovascular risks
                                                1. Thrombosis risk
                                                  1. Acute
                                                    1. Heparin
                                                    2. Long term
                                                      1. Warfarin (INR 2-3) or antiplatelet
                                                    3. In pregnancy
                                                      1. LMWH + aspirin

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