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Antiphospholipid syndrome

Description

Mind Map on Antiphospholipid syndrome, created by Laura Smitherman on 16/02/2015.

Mind Map by Laura Smitherman, updated more than 1 year ago

	Created by Laura Smitherman almost 10 years ago

115

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Resource summary

Antiphospholipid syndrome

Cause
1. autoimmune
  1. ?antiphospholipid antibodies
    1. lupus anticoagulant
    2. anti-cardiolipin
    3. anti-β2-glycoprotein-I
  2. complement and platelet activation
2. genetic
3. unknown
presentation
1. hypercoagulable state
  1. venous
    1. DVT
    2. PE
  2. arterial
    1. stroke
2. pregnancy complications
  1. stillbirth
  2. miscarriage
  3. preterm delivery
  4. severe pre-eclampsia
3. Livedo reticularis
4. haemolytic anaemia
5. thrombocytopenia
Types
1. Primary
  1. HLA-DR7
2. Secondary
  1. risk factors
    1. associated with other autoimmune diseases e.g. SLE, RA
    2. HLA-B8, HLA-DR2, HLA-DR3
    3. ethnicity
    4. most common in young fertile women
Management
1. Lifestyle to reduce cardiovascular risks
2. Thrombosis risk
  1. Acute
    1. Heparin
  2. Long term
    1. Warfarin (INR 2-3) or antiplatelet
3. In pregnancy
  1. LMWH + aspirin

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