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29189527
Mapa Creativo Fisiopatología del Choque Séptico
Description
Mapa Creativo de la Fisiopatología del Choque Séptico.
Mind Map by
Diana Tigasi
, updated more than 1 year ago
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Created by
Diana Tigasi
about 4 years ago
38
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Resource summary
Mapa Creativo Fisiopatología del Choque Séptico
La piedra angular del estado de choque
Deficiencia en la perfusión a nivel tisular
condiciona
Cambios bioquímicos citotóxicos
es la:
se caracteriza por:
RESPUESTA PROINFLAMATORIA
Factores:
Edad
Medicamentos
genéticos
A nivel:
Tisular
Vascular
ENDOTOXINAS BACTERIANAS
Componente:
LIPOPOLISACÁRIDO
Cambios fisiológicos como:
1.Manifestaciones clínicas similares en la infección
2. Cambios hematológicos
3. Activación del factor Hageman de la coagulación
4. Liberación del factor de necrosis tumoral (TNF)α e IL-1( protege contra los efectos letales de la administración de endotoxinas)
CITOCINAS
provocan
Efectos tóxicos en los tejidos
Promoción de adhesión leucocitaria a la célula endotelial
La liberación de proteasas
Disrupción de la cascada de la coagulación y del sistema fibrinolítico.
a través
Derivados del ácido araquidónico:
ocaciona
Daño de células endoteliales de los vasos sanguíneos
afectando
PERFUSIÓN TISULAR
La proteína C activada
Interleucina 1
TNFα
Aumenta
Producción del inhibidor del activador de plasminógeno
- Difusión de oxígeno - Disfunción mitocondrial
La:
Mala distribución del flujo sanguíneo
produce
Cambios hemodinámicos
Gasto cardíaco
-Resistencia vascular periférica -Retorno venoso
FALLA MULTIORGÁNICA
Riñón
Pulmón
Hígado
Cerebro
Corazón
Defecto de la extracción tisular
Por:
> O2 durante la infección
MEDIADORES PRO INFLAMATORIOS Se rompe
Tisular alterada de O2
consecuencia
Pérdida de embarazo
Muerte Materna
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