Women and Heart Disease

Annotations:

• https://www.goredforwomen.org/home/about-heart-disease-in-women/facts-about-heart-disease/

1. Psychological stress

   Annotations:

   • http://www.ahjonline.com/article/S0002-8703(14)00560-2/pdf http://news.emory.edu/stories/2013/11/stress_vaccarino_aha/index.html
2. Inflammation

   Annotations:

   • http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/rheumatology/cardiovascular-risk-and-prevention-in-rheumatic-disease/Default.htm http://circ.ahajournals.org/content/109/21_suppl_1/II-2.full
3. Increased mortality with MI
4. Microvascular disease vs. Macrovascular disease
   1. Microvascular disease

      Annotations:

      • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132073/
      • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132073/
      1. testing with Coronary flow reserve (CFR)
      2. WISE study
   2. Macrovascular disease
      1. stress testing

         Annotations:

         • Heart rate Response to Exercisehttp://circ.ahajournals.org/content/122/2/130.abstract Role of Non-invasive testing in eval of IHD http://circ.ahajournals.org/content/130/4/350jkey=d00abb8fc5875319164036e64ddc9f2e9a52553a&keytype2=tf_ipsecsha CI and maximal HR prediction http://circ.ahajournals.org/content/123/9/1010.full
         1. WOMENs trail - Lessless Shaw

            Annotations:

            • low risk women who can do maximal exercise ( 8.5 - 10 METs, 10 min Bruce equivalent) same 2 yr outcomes compared to SPECT(presented at AHA, 2010)
5. Erosive vs. Explosive plaque
6. Unique symptoms