3289361
Description
Mind Map by puma_1921paul, updated more than 1 year ago
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Created by puma_1921paul
almost 9 years ago
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HER2 +
- Human epidermal growth factor receptor
- Locus Citogenético 17q12–21.32
- Other genes
BRCA1, TOP2A,
TP53
- Other genes
BRCA1, TOP2A,
TP53
- Expresado en 20 % de los cánceres
(Amplificación ERBB2)
- poor prognostic
more aggressive
decreased survival
- Locus Citogenético 17q12–21.32
- Treatment
- Trastuzumab
(monoclonal antibody)
- Trastuzumab
(monoclonal antibody)
- diagnostic techniques
- immunohistochemistry (IHC)
- in situ hybridization (ISH)
- ≥3 CEP17
(Cuttoff)
- immunohistochemistry (IHC)
- Gene amplification
- Increase in the copy
number of a specific
chromosomal region
- Polisomia
- Presence of extra copies
of one or more whole
chromosomes
- Presence of extra copies
of one or more whole
chromosomes
- disomía uniparental
- dos copias de un
cromosoma provienen del
mismo progenitor
- dos copias de un
cromosoma provienen del
mismo progenitor
- Increase in the copy
number of a specific
chromosomal region
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