RHEUMATOID ARTHRITIS

Description

Mind Map on RHEUMATOID ARTHRITIS, created by Marwa Alqassim on 14/02/2022.
Marwa Alqassim
Mind Map by Marwa Alqassim, updated more than 1 year ago
Marwa Alqassim
Created by Marwa Alqassim over 2 years ago
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Resource summary

RHEUMATOID ARTHRITIS
  1. autoimmune disease caused by loss of self-tolerance
    1. 1- Bystander T cell activation
      1. 2- Molecular mimicry
        1. 3- Polyclonal lymphocyte activation
          1. 4- Altered self
            1. 5- Release of sequestered antigens
              1. 6- Availability of cryptic epitopes
    2. Pathogenesis
      1. Investigations
        1. X-ray ,MRI
          1. Anti CCP , RF
            1. clinical examination
            2. Complications
              1. Managment
                1. Pharmacological
                  1. DMARDs
                    1. NSAIDs
                      1. Corticosteroids
                        1. Biologic therapies
                  2. Non-Pharmacological
                    1. Exercise
                      1. Relax
                        1. Surgery
                      2. prognosis
                        1. depends on
                          1. age , symptoms , disease condition
                        2. Epidimelogy
                          1. Psychological Effect
                            1. affects
                              1. Hand
                                1. Examination
                                  1. Inspection,Palpation, and ROM
                                    1. Phalen’s . Tinel’s , Finkelstein’s tests
                                  2. Bones
                                    1. carpals , metacarpals , phalanges
                                    2. Joints
                                      1. Swollen Joints
                                        1. acute
                                          1. chronic
                                            1. Osteoarthritis
                                              1. Rheumatoid Arthritis
                                                1. Gout
                                              2. wrist , carpal , CM , MP , IP
                                                1. all are synovial
                                                  1. Synovial Fluid
                                                    1. contains
                                                      1. Water , Inorganic salts Hyaluronic acid ,Lubricin
                                                        1. Neutrophils ,Lymphocytes Monocytes, Macrophages
                                                2. Intrinsic Muscles
                                                  1. thenar , hypothenar , lumbricals , interossei , palmaris brevis , adductor pollicis
                                                  2. Blood Supply
                                                    1. superficial & deep arches
                                                    2. Nerves
                                                      1. ulnar , median , radial
                                                  3. Infertility
                                                    1. not being able to get pregnant (conceive) after 1 year of unprotected sex
                                                      1. Causes
                                                        1. Women
                                                          1. PCOS
                                                            1. Endometriosis
                                                              1. Ovulation disorders
                                                          2. Men
                                                            1. Varicocele
                                                              1. Undescended testes
                                                                1. Abnormal sperm production or function
                                                          3. Risk factors
                                                            1. Age
                                                              1. Alcohol
                                                                1. Smoking
                                                                  1. Stress
                                                                    1. Radiation therapy
                                                            2. Types
                                                              1. Primary
                                                                1. Secondary
                                                                2. Pathophysiology
                                                                  1. Investigations
                                                                    1. Blood test
                                                                      1. Hormone studies
                                                                        1. Sperm antibodies
                                                                          1. Ultrasound
                                                                    2. Management
                                                                    3. Anatomy
                                                                      1. Histology
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