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Hereditary WBC Disorders

Description

Mind Map on Hereditary WBC Disorders, created by KevinShirley on 20/11/2013.
KevinShirley
Mind Map by KevinShirley, updated more than 1 year ago
KevinShirley
Created by KevinShirley about 11 years ago
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Resource summary

Hereditary WBC Disorders
  1. May-Hegglin Anomaly
    1. Associated Conditions

      Annotations:

      • Abnormal bleeding may be present in some individuals.
      1. thrombocytopenia
        1. giant platelets
        2. WBC's affected
          1. neutrophils
          2. appearance
            1. Döhle-like bodies

              Annotations:

              • Rod shaped inclusions at the edge of the cytoplasm. They are like Döhle bodies but larger.
            2. prevalence
              1. unknown
            3. Alder-Reilly Anomaly
              1. Associated Conditions
                1. dwarfism
                  1. gargoylism
                  2. WBC's affected
                    1. All cell lines
                      1. hallmark feature
                    2. Appearance
                      1. coarse dark granulation
                      2. prevalence
                        1. rare
                      3. Pelger-Huet Anomaly
                        1. prevalence
                          1. common
                          2. associated conditions
                            1. leukemias
                              1. myleoproliferative disorders
                                1. severe infections
                                2. WBC's affected
                                  1. segmented neutrophils
                                  2. appearance
                                    1. hyposegmentation of nucleus
                                      1. heterozygotes
                                        1. peanut-shaped
                                          1. dumbbell-shaped
                                            1. pince-nez-shaped
                                            2. homozygotes
                                              1. spherical non-lobed
                                        2. Chediak-Higashi Syndrome
                                          1. prevalence
                                            1. rare
                                            2. associated conditions
                                              1. neutropenia
                                                1. albinism
                                                  1. photophobia
                                                    1. recurrent staphylococcus infections
                                                    2. WBC's affected
                                                      1. neutrophils (mostly)
                                                        1. lymphocytes
                                                          1. monocytes
                                                          2. appearance
                                                            1. giant purple-gray granules
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