468699
Description
Mind Map by v.djabatey, updated more than 1 year ago
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Created by v.djabatey
almost 11 years ago
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Malabsorption
- manifestations of disorders affecting digestion
or absorption of nutrients
- abnormal stools
- true malabsorption stool
- hard to flush down the toilet
- odour pervades whole house
- hard to flush down the toilet
- colour is poor guide to
abnormality
- true malabsorption stool
- failure to thrive or poor growth
- seen in most but not all cases
- inapprop to ix kids for malabsorption as a cause
of failure to thrive when dietary intake is low &
other sx absent
- seen in most but not all cases
- specific nutrient deficiencies
- abnormal stools
- reliable dietary assessment is important
- can be pan-malabsorption
- poor absorption of many nutrients
- poor absorption of many nutrients
- can be highly specific
- e.g. Zn malabsorption
- acrodermatitis enteropathica
- acrodermatitis enteropathica
- e.g. Zn malabsorption
- causes of nutrient malabsorption
- cholestatic liver disease or
biliary atresia
- bile salts no longer enter
duodenum in bile
- -> defective solubilisation of products
of triglyceride hydrolysis
- -> fat and fat-soluble malabsorption
- -> fat and fat-soluble malabsorption
- -> defective solubilisation of products
of triglyceride hydrolysis
- bile salts no longer enter
duodenum in bile
- exocrine
pancreatic
dysfunction
- e.g cystic fibrosis
- absent lipase, proteases & amylase
- -> defective triglyceride, protein and starch
digestion (pan-malabsorption)
- -> defective triglyceride, protein and starch
digestion (pan-malabsorption)
- e.g cystic fibrosis
- small intestinal mucosal disease
- loss of absorptive surface area
- e.g. coeliac disease
- e.g. coeliac disease
- specific enzyme defects
- e.g. lactase deficiency ff
gastroenteritis
- common in Black & Oriental races
- common in Black & Oriental races
- e.g. lactase deficiency ff
gastroenteritis
- specific transport defects
- e.g. glucose-galactose malabsorption
- severe life-threatening diarrhoea with 1st milk feed
- severe life-threatening diarrhoea with 1st milk feed
- acrodermatitis enteropathica
- zinc malabsorption
- erythematous rash of mouth &
anus
- erythematous rash of mouth &
anus
- zinc malabsorption
- e.g. glucose-galactose malabsorption
- loss of absorptive surface area
- lymphatic leakage or
obstruction
- chylomicrons (containing absorbed
lipid) unable to reach thoracic duct &
sys circulation
- e.g. intestinal lymphangiectasia
(abnormal lymphatics)
- e.g. intestinal lymphangiectasia
(abnormal lymphatics)
- chylomicrons (containing absorbed
lipid) unable to reach thoracic duct &
sys circulation
- short bowel syndrome
- small intestinal resection
- due to congenital
abnormalities or
necrotising enterocolitis
- -> nutrient, water & electrolyte
malabsorption
- due to congenital
abnormalities or
necrotising enterocolitis
- small intestinal resection
- loss of terminal ileal function
- e.g. resection or Crohn disease
- absent bile acid and absent B12 absorption
- e.g. resection or Crohn disease
- cholestatic liver disease or
biliary atresia
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