492577
Description
Mind Map by jenny schneider, updated more than 1 year ago
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Created by jenny schneider
almost 11 years ago
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Therapeutic Drug Monitoring
- Assay techniques
- Assays using antibodies
- FPIA, RIA, EMIT
- Advantages: rapid, less training, small sample size
- Disadvantages: less specific (cross-react)
- FPIA, RIA, EMIT
- chromatography techniques
- GC, HPLC
- Advantages: better specificity; good for research applications
- Disadvantages: equipment costly, needs bigger sample size, not as quick as antibody methods, need more training
- GC, HPLC
- Assays using antibodies
- Blood Sampling
- correct time- usually trough level
- correct type of tube
- correct handling and storage
- correct time- usually trough level
- Assay requirements
- Reproducible, accuracy and precision
- Reproducible, accuracy and precision
- Interpreting TDM result clinically
- look at result AND patient response
- Consider patient factors- e.g. disease, age
- consider assay used and sample collection/handling
- sample taken at correct time?
- what is dosage regimen and when last dose was taken
- look at result AND patient response
- good candidate for TDM
- good correlation between concentration and effect
- therapeutic range defined
- narrow therapeutic index
- large interindividual variability
- effect cannot be measured by simpler method
- good correlation between concentration and effect
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