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52208
central monoamines
Description
Neuroscience of Pain Mind Map on central monoamines, created by Cher Bachar on 21/04/2013.
No tags specified
neuroscience of pain
neuroscience of pain
Mind Map by
Cher Bachar
, updated more than 1 year ago
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Created by
Cher Bachar
over 11 years ago
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Resource summary
central monoamines
serotonin
Regulation of nociception
endogenous analgesia
Role of 5-HT1 agonists in migrane
Anatomical and functional organisation
RVM
serotonin neurons= NEUTRAL cells
Receptors
5-HT1
inhibit nociception
5-HT2/3
facilitate nociception
5-HT7
periphery-pronociceptive
spinal cord-antinociceptive
Noradrenaline
Regulation of nociception
Anatomical and functional organisation
NA neurons
7 groups in the brainstem
Annotations:
A1-A7
Adrenoceptors
At spinal level
Alpha1
Annotations:
excitatory via phospholipase C- increased PI and DAG
Alpha2
Annotations:
inhibition of adenylyl cyclase- decrease cAMP- like opiod receptors>> main focus because they mimic opiods
Beta
Annotations:
excitation via increase cAMP
Phrmacology
intrathecal drugs
Annotations:
injected in the CSF of the spinal cord
allpha-adrenoceptor anta
blocks Locus coereleus (LC) evoked analgesia
blocks PAG/RVM evoked analgesia
NA agonists
via alpha2 receptors
in rats
in humans
analgesic effects
side effects
hypotension
sedation
Activation
electrical or chemical
LC, A7- antinociceptive
Descending NA control
Methods
Animals
stimulation of pontine N
electrical
chemical
recording LC neurons
Lesions
electrical of LC
chemical
antagonists
alpha1/2
knockouts of alpha2 receptors
Vital targeting
Humans
alpha agonists
NA re-uptake inhibitors
Role
inflammatory pain
neuropathic pain
endogenous analgesia
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