THIRD LINE IMMUNE RESPONSE

1. CHARACTERISTICS
   1. SPECIFIC
   2. ACTIVATE AFTER INFECTION
   3. THE MAGNITUDE FOR SECOND INFECTION IS HIGHER COMPARED FOR THE FIRST TIME
   4. MEMORY OF PREVIOUS INFECTION IS STORED

1. LYMPHOCYTE DEVELOPMENT
   1. T CELLS (THYMUS)
   2. B CELLS (BONE MARROW
2. FUNCTION
   1. BIND TO RECEPTOR OF OTHER CELL
   2. BIND TO THE ANTIGEN
   3. TRANSMIT AND RECEIVE MESSAGE

1. SUBSTANCE THAT PROVOKE THE IMMUNE RESPONSE
   1. EPOTOPE IS ANTIGENIC SPECIFICITY

1. FACTOR
   1. -SIZE , COMPLEXITY, FOREIGN

1. CLASS 1
   1. EXPRESSE ON ALL NUCLEATED CELL
2. CLASS II
   1. ON ANTIGENT PRESENTING MICROPHAGES
3. CLASS III
   1. FOUND IN PROTEIN

1. HELPER T CELLS

   Annotations:

   • Stimulate or activate other cell release cytokines
2. memory t cells

   Annotations:

   • store the memory after 1 infection
3. regulatory t cells

   Annotations:

   • -regulate other -prevent inflammation
4. CYTOTOXIC T CELLS

   Annotations:

   • Have granzymes and perforinse to kill the bacteria -attack cancer cell and foreigner

Annotations:

• -can activate without helper T cell (independant cases) -B cell can activate by helper T cell (MAJOR)

1. diffrentiate
   1. memory B cell
   2. regulatory B cell

      Annotations:

      • -act same as regulatory T cell
   3. plasma cell
      1. release antibodies
         1. ANTITOXIN ACTION
         2. NEUTRALISATION
         3. AGGLUTINATION
         4. OPSONISATION