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530357
Interferons
Description
Mind Map on Interferons, created by ccoyle52 on 06/02/2014.
Mind Map by
ccoyle52
, updated more than 1 year ago
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Created by
ccoyle52
over 10 years ago
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Resource summary
Interferons
Function
Induction of cellular resistance to Viral Attack
Regulates most aspects of immune function
Growth & Differentiation of many cell types
Sustenance of early phases of pregnancy
Classes
Alpha
2 classes- Type1(15) & Type 2(1)
Type 1 =166 amino acids
Type 2= 172 amino acids
Glycolylation: post translational modification carbohydrate linkage
O- Linkage binding only to Serine(S) & Tyrosine(Y)
N- Linkage Binding only to Asparagine(N)
rich in leucine & glutamic acid & display conserved cysteines.These generally form 2 disulfide bonds in mature molecule
Beta
Gama
Receptors
Gama type 2 Receptor
Signal Transduction
Cell types that display Gama Receptor Haematopoietic cells(Blood cell types)
Transmembrane glycoproteins(molecular mass 50kDa and appear as homodimer
Extracellular gama binding site consists of 200 amino acids folded into 2 homologous domains
It also requires second transmembrane glycoprotein( accessory factor 1) that interacts with the extracellular region
Jak-Stat
(1)Ligand induces receptor dimerisation
(2)JAK induces reciprocal tyrosine phosphorylation of JAKs associated withthe receptors cytoplasmic tail
(3)Phosphorylated JAKs phosphorylate tyrosine residues within the receptors cytoplasmic tail used as a docking site for STAT
(4) This phosphorylation Induces dimerisation of STAT.Dimerised STAT Translocates to the nucleus where it binds to Specific DNA RESPONSE ELEMENTS
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