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G Protein Coupled Receptors (as a system)
Description
Mind Map on G Protein Coupled Receptors (as a system), created by Laura Young on 25/04/2013.
Mind Map by
Laura Young
, updated more than 1 year ago
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Created by
Laura Young
over 11 years ago
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Resource summary
G Protein Coupled Receptors (as a system)
Heterotrimeric G Proteins
Gs Family
Activate adenylate cyclase
regulate PKA, protein kinase A
Gi Family
i = inhibit
inhibit adenylate cyclase
Gq Family
q.. P.. r s etc
i.e. P comes after Q
activates Phospholipase C
regulates PKC and IP3
PKA
B adrenoceptor activation by adrenaline
In heart cAMP increases strength and rate of heart rate (B1)
In lungs cAMP relaxes bronchial smooth muscle (B2)
B Adrenoceptors
Agonists in the lung
Salbutamol
B2 selective
dilates bronchial smooth muscle, eases respiration
used in asthma
Antagonists in the heart
B1 Selective
Atenolol
competitive reversible antagonist
slows heart rate, reduces force of beat
A Adrenoceptors
Activated by epinephrine
related to Gq family
IP3 releases Ca2+ from the sacroplasmic reticulum
DAG opens Ca2+ channel
Ca2+ flows
increase in Ca2+ at intracellular level
Pharmacology of A1 adrenoceptor
Prazosin
competitive, reversible antagonist at a1 adrenoceptor
Prevents contraction of SM in blood vessel wall
Blood vessels dilate so BP falls
Receptor Tyrosine Kinases (RTKs)
Tyrosine Kinase definition
an enzyme that can transfer a phosphate group to a tyrosine residue in a protein
Tyrosine kinase coupled receptors
found on cell membrane
receptors for hormones/growth factors
express tyrosine kinase activity
combine to form dimers
affect cell metabolistm
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