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6056225
Th1L07 Clinical use of enzyme measurements
Description
Medicine Y1 (Theme 1 | Cells and organelles) Mind Map on Th1L07 Clinical use of enzyme measurements, created by Emma Allde on 17/08/2016.
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medicine y1
theme 1 | cells and organelles
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Emma Allde
, updated more than 1 year ago
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Created by
Emma Allde
about 8 years ago
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Resource summary
Th1L07 Clinical use of enzyme measurements
Appearance of creatine kinase and lactate dehydrogenase in plasma after myocardial infarction
Increase in CK2 activity 24 hours after
Increase in LDH activity 48 hours after
Isozymes of lactate dehydrogenase can be separated by chromatography
five different isozymes of lactate hydrogenase exist
H4, H3M, H2M2, HM3 and M4
During a myocardial infarction
Endothelial cells rupture, releasing their contents into the blood stream
This increases the serum levels for lactate hydrogenase isozyme 1 and 2 and cane be used as a diagnostic tool
composed of four monomers
heart or muscle type
Clinical uses of enzyme inhibitors
Control of angiotensin production
cleavage of Angiotensin I to Angiotensin II results in peripheral vasoconstriction and aldosterone secretion
Treatment of heart failure with ACE inhibitors prevents sodium/water retention > oedema
Enzyme inhibitors as toxins
Mustard gas, sarin (nerve gases)
Organophosphorus
Inhibits cholinesterase irreversibly; poisons the enzyme
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