ANTIBIOTICS-1

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Mind Map on ANTIBIOTICS-1, created by naila.k.ferris on 17/03/2014.
naila.k.ferris
Mind Map by naila.k.ferris, updated more than 1 year ago
naila.k.ferris
Created by naila.k.ferris over 10 years ago
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Resource summary

ANTIBIOTICS-1
  1. Inhibition of cell wall synthesis

    Annotations:

    • bind to cyto PBP, inh. transpeptidation, inh. cross-linking of bacterial cell wall
    1. PENICILLINS, CEPHALOSPORINS,
      1. IMIPENEM, MEROPENEM, ASTREONAM VANCOMYCIN

        Annotations:

        • vancomycin - Inhibits peptidoglycan synthases bind to D-Alanine
        1. B-lactamase cleavage of drugs B-lactam ring
      2. Inhibition of protein synthesis
        1. Interfere with formation of initiation complex
          1. BACTERICIDAL

            Annotations:

            • misread genetic code carried by mRNA resulting in the incorperatino of wrong aa
            1. AMINOGLYCOSIDE (30S), LINEZOLID (50S)
              1. production of conjugatingenzymes that increase drugs clearance
          2. Interfere with incorporation of next aa
            1. BACTERIOSTATIC

              Annotations:

              • inh. insertion of aminoacyl t-RNA into "A" site
              1. TETRACYCLINS (30S), DILFOPRISTIN & QUINUPRISTIN (50S)
                1. production of active transport systems that push drugs out of the cell

                  Annotations:

                  • tetracyclins
            2. Interfere with formation of peptide bond
              1. BACTERIOSTATIC

                Annotations:

                • inh. peptidyltransferase
                1. CHLORAMPHENICOL
                  1. formation of acetylating ensymes that inactivate drugs

                    Annotations:

                    • chloramphenicol
              2. Interfere with translocation
                1. BACTERIOSTATIC

                  Annotations:

                  • Inh. translocation of peptidyl-tRNA from acceptor donor site
                  1. MACROLIDE (50S), CLINDAMYCIN(50S)
                    1. methylation of base in RNA that alter drugs binding

                      Annotations:

                      • macrolides
              3. Inhibiiton of folic acid synthesis
                1. SULFONAMIDE

                  Annotations:

                  • inh. duhydropteroate synthetase
                  1. formation of a PABA, increase resistance to inhibition of dihydropteroate synthetase
                  2. TRIMETHOPRIN & PYRIMETHAMINE

                    Annotations:

                    • inh. dihydrofolate reductase
                  3. Inhibition of nucleic acid synthesis
                    1. FLUOROQUINOLONES

                      Annotations:

                      • inh. DNA gyrase (topiosomerase 2)
                      1. increase transport systems to push drugs out. increase resistance to inh. of topio. 2

                        Annotations:

                        • antibiotic resistance.  R-factor plasmid-mediated transmission. selection of resistance cells 
                      2. RIFAMPIN

                        Annotations:

                        • inh. DNA-dep RNA polymerase
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