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WBC disorder

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Mind Map on WBC disorder, created by Abdulla Nidal on 07/05/2017.
Abdulla Nidal
Mind Map by Abdulla Nidal, updated more than 1 year ago
Abdulla Nidal
Created by Abdulla Nidal over 7 years ago
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Resource summary

WBC disorder
  1. Complications
    1. Infections
      1. Secondary cancers
        1. Anemia
          1. Bleeding disorders
          2. Treatment
            1. Chemotherapy
              1. Terosine kinase inhibitors
                1. first generation
                  1. Imatinib
                  2. Second generation
                  3. Other
                    1. Methotrexate
                      1. Folic acid
                        1. Antimetabolite
                      2. Bone marrow transplant
                        1. HLA typing
                          1. GvH reaction
                        2. Investigation
                          1. History taking
                            1. Ask for
                              1. Fatigue, fever, weight loss, discoloration
                            2. Blood test
                              1. CBC
                                1. LAP
                                  1. Blood film
                                  2. Other(genetic)
                                    1. FISH
                                      1. To see the morphology of chromosome
                                        1. Karyotype
                                    2. Sign and symptom
                                      1. Vast disorders
                                        1. Fever
                                          1. Chills
                                            1. Fatigue
                                              1. Tenderness and pain
                                                1. Easy bleeding
                                                2. Specific
                                                  1. ALL
                                                    1. BM suppression
                                                    2. AML
                                                      1. Chloroma
                                                        1. Gingivitis
                                                        2. CLL
                                                          1. Lymphadenopathy
                                                          2. CML
                                                            1. Huge splenomegaly
                                                        3. Hematopoiesis
                                                          2. Causes
                                                            1. Leukemia
                                                              1. Translocation
                                                                1. Inhibitor of apoptosis
                                                                  1. Mutation in Terosine kinase proncogene
                                                                  2. Leukocytosis
                                                                    1. Infection
                                                                      1. Allergy
                                                                        1. irritants
                                                                        2. Leukopenia
                                                                          1. HIV
                                                                            1. Autoimmune
                                                                              1. Chemo
                                                                            2. Pathophysiology
                                                                              1. Leukopenia
                                                                                1. Neutropenia
                                                                                  1. Decreased granulocyte production
                                                                                    1. Will increase risk of bacterial infection
                                                                                    2. Increased gran. desctruction
                                                                                    3. Lymphopenia
                                                                                      1. Not common
                                                                                        1. Leads to Viral infection
                                                                                    4. Leukocytosis
                                                                                      1. Reactive leukocytosis
                                                                                        1. Neutrophil
                                                                                          1. Bacteria
                                                                                          2. Eosinophil
                                                                                            1. Allergy
                                                                                            2. Basophil
                                                                                              1. Rare
                                                                                              2. Monocyte
                                                                                                1. Chronic infection
                                                                                              3. Leukomoid reaction
                                                                                                1. Mimics leukemia
                                                                                                  1. increased LAP
                                                                                                2. Leukemia
                                                                                                  1. Lymphoid
                                                                                                    1. Chronic
                                                                                                      1. Most common leukemia
                                                                                                        1. B-cel hyperproliferation
                                                                                                          1. 50+ years
                                                                                                          2. Acute
                                                                                                            1. <15 years
                                                                                                              1. Tdt +ve
                                                                                                                1. Lymph adenopathy
                                                                                                                  1. Clumped chromatin
                                                                                                                  2. Myeloid
                                                                                                                    1. Chronic
                                                                                                                      1. 25-60 years
                                                                                                                        1. Extramedullary hematopoeisis
                                                                                                                          1. indolent
                                                                                                                          2. Acute
                                                                                                                            1. Immature blast cells
                                                                                                                              1. PAN cytopenia
                                                                                                                                1. Lacy chromatin

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