8921957
Description
Mind Map by semoxmrx ., updated more than 1 year ago
|
Created by semoxmrx .
about 7 years ago
|
|
Sana with rash and easy
Bruising
- Hemostais
- The three steps are
- 1- vascular
constriction
- 2- platelet
plug
- 3- coagulation
- 1- vascular
constriction
- Physiology of Coagulation
- Extrinsic pathway → begins
with trauma to the vascular
wall & surrounding tissues.
- Intrinsic pathway →
begins in the blood
itself.
- Extrinsic pathway → begins
with trauma to the vascular
wall & surrounding tissues.
- Bleeding Disorders
- Vascular bleeding disorders
- 1-Congenital defects of the
vessel wall Ehlers- Danlos
syndrome
- 2-Senile purpura: defect in the
subcutaneous tissue
supporting the bvs
- 3-Scurvy vitamin C
deficiency
- 4- Septic Vasculitis
Infections
- 5-Henoch-Schonlein Purpura
- 1-Congenital defects of the
vessel wall Ehlers- Danlos
syndrome
- Platelets disorders
- Number :Thrombocytopenia
(ITP)
- Incidence
- in adults is approximately 66
cases per 1,000,000 per year
- in children is 50 cases
per 1,000,000 per year
- in adults is approximately 66
cases per 1,000,000 per year
- etiology
- immune system mistakenly
attacking and destroying
platelets
- immune system mistakenly
attacking and destroying
platelets
- Clinical
manifestations
- excessive bruising
(purpura)
- Bleeding from the gums or
nose
- Blood in urine or stools
- petechiae
- epistaxis
- excessive bruising
(purpura)
- CHILDHOOD VS ADULT
- Chronic ITP (adult)
- persists longer than 6
months without a
specific cause.
- Acute ITP (childern)
- young children (2 to 6
years old)
- symptoms may follow a
viral illness
- symptoms usually
disappear in less than six
months
- Chronic ITP (adult)
- Management
- Treatment in children
- do not require treatment, and
thrombocytopenia resolves
spontaneously.
- do not require treatment, and
thrombocytopenia resolves
spontaneously.
- Treatment in adults
- Corticosteroids such as prednisone
- cataracts, high blood
sugar, increased risk of
infections and
Osteoporosis
- cataracts, high blood
sugar, increased risk of
infections and
Osteoporosis
- IVIG
- headache, vomiting and
low blood pressure
- headache, vomiting and
low blood pressure
- Thrombopoietin receptor agonists
- headache, dizziness,
nausea or vomiting, and an
increased risk of blood
clots
- headache, dizziness,
nausea or vomiting, and an
increased risk of blood
clots
- Corticosteroids such as prednisone
- Surgical care:
- splenectomy
- serious post-surgical
complications, and not
having a spleen
permanently increases your
susceptibility to infection
- the surgical
removal of the
spleen.
- In ITP, the antibody-coated
platelets are often removed
from circulation by the
spleen.
- Theoretically, if the spleen
is removed, the platelets
will remain in the blood
stream.
- The spleen can also be the site of
antibody production. Therefore
removing the spleen may reduce the
amount of anti-platelet antibodies in
addition to removing the
antibody-coated platelets.
- Theoretically, if the spleen
is removed, the platelets
will remain in the blood
stream.
- serious post-surgical
complications, and not
having a spleen
permanently increases your
susceptibility to infection
- splenectomy
- SIDE EFFECTS
- Treatment in children
- pathogenesis
- an abnormal autoantibody, usually
immunoglobulin G (IgG) with specificity for one or
more platelet membrane glycoproteins, binds to
circulating platelet membranes.
- Autoantibody-coated platelets
induce Fc receptor-mediated
phagocytosis by mononuclear
macrophages
- mononuclear macrophages
in the red pulp destroy
immunoglobulin-coated
platelets
- mononuclear macrophages
in the red pulp destroy
immunoglobulin-coated
platelets
- Autoantibody-coated platelets
induce Fc receptor-mediated
phagocytosis by mononuclear
macrophages
- an abnormal autoantibody, usually
immunoglobulin G (IgG) with specificity for one or
more platelet membrane glycoproteins, binds to
circulating platelet membranes.
- Incidence
- Function: Disorders of
platelet function
- Acquired: Aspirin- uremia
(RF)-MPD Inherited : von
Willebrand Disease
- Number :Thrombocytopenia
(ITP)
- Coagulation disorders
- – Congenital: – hemophilia A – Factor VIII (8) _
Intrinsic pathway – Hemophilia B –Christmas disease
-Factor IX(9) _ Intrinsic pathway – Von willebrand
diseasen
- – Acquired : – liver
disease
- – Congenital: – hemophilia A – Factor VIII (8) _
Intrinsic pathway – Hemophilia B –Christmas disease
-Factor IX(9) _ Intrinsic pathway – Von willebrand
diseasen
- Vascular bleeding disorders
- investigation
- DEMOGRAPHY
- Sana , 28-Years Old, Female
- Sana , 28-Years Old, Female
Media attachments
Want to create your own Mind Maps for free with GoConqr? Learn more.