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933603
Penicillin
Description
Edexcel iGCSE history
No tags specified
penicillin
antibiotics
fleming
gcse history
history
changes in medicine 1845-1945
a-level
Mind Map by
Niamh MacElvogue
, updated more than 1 year ago
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Created by
Niamh MacElvogue
over 10 years ago
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Resource summary
Penicillin
Fleming
First to publish findings on penicillin although...
1870s - Sanderson observed that very little grew near penicillin mould
Lister successfully used on a nurse but took it no further
He was first to realise the potential significance
Sent to work in a hospital (WW1)
Working to kill staphylococcus germ
Mould grew mistakenly on a germ plate and he realised that it had killed the germs (1928)
1929 - Published a report of his findings
No one took notice at the time
Florey and Chain
Became interested in penicillin in the 1930s
Fleming had since lost interest
Applied to government for money to begin research
Received only £25 but were lucky to get this much as by 1939, WWII had begun
Despite the lack of money, they managed to produce enough to test on 8 mice
This was successful
Needed 3000 times more to test on a human
Over some months they collected enough penicillin to use on one human
The man they tested on was a man called Albert Alexander (1940)
The treatment was successful until they ran out and he passed away
However it was successful as it proved penicillin's success
1941 - US government approached for funding to mass produce and it was given
1943 - enough to treat 1000 men, by 1944 - enough to treat 40,000 cases, at the end of the war - enough for 250,000
Importance of penicillin
15% of soldiers could have died without it
After the war, the antibiotic was made widely available and saved the lives of millions
The diseases that penicillin treats includes bronchitis, pneumonia and meningitis
More antibiotics followed including mitomycin in 1956 which is a chemotherapy drug
1000s of injured soldiers could return to battle more quickly
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