Michael Jardine
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PHSI3011 01-2 Cardiac excitation-contraction coupling 1 - Channels, exchangers, pumps

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Michael Jardine
Created by Michael Jardine about 7 years ago
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PHSI3011 01-2 Cardiac excitation-contraction coupling 1 - Channels, exchangers, pumps

PHSI3011 01-2 Cardiac excitation-contraction coupling 1 - Channels, exchangers, pumps

Question 1 of 6

1

Which of the following is NOT a type of Calcium channel?

Select one of the following:

  • G-type

  • L-type

  • N-type

  • T-type

Explanation

Question 2 of 6

1

An L-type Calcium channel has how many subunits?
(each controlled by a separate gene)

Select one of the following:

  • 2

  • 3

  • 4

  • 5

  • 6

  • 7

  • 8

Explanation

Question 3 of 6

1

An L-type Calcium channel is highly selective for Calcium, but is also somewhat permeable to Sodium and Potassium.

Select one of the following:

  • True
  • False

Explanation

Question 4 of 6

2

During diastole, the Na/Ca exchanger and the SR Ca pump both move Ca. Which way around?

Select one of the following:

  • Na/Ca exchanger will pull Ca IN to the myoplasm; the SR Ca pump will pump Ca back INTO the SR.

  • Na/Ca exchanger will pull Ca IN to the myoplasm; the SR Ca pump will pump Ca back OUT of the SR.

  • Na/Ca exchanger will push Ca OUT from the myoplasm; the SR Ca pump will pump Ca back INTO the SR.

  • Na/Ca exchanger will push Ca OUT from the myoplasm; the SR Ca pump will pump Ca back OUT of the SR.

Explanation

Question 5 of 6

3

Select from the dropdown lists to complete the text.

The longitudinal SR contains a high concentrations of proteins acting as an ATP-dependent Ca pump - returning Ca from the myoplasm to the SR lumen (to help terminate contraction).
These proteins are called SERCA.
What does SERCA stand for?
( Sarco, Sarcoplasmic ) ( Endo, Endoplasmic ) ( [plasmic] Reticulum, [plasmic] Ryanodine ) ( Calcium, Concentration ) ( Activation, Activator, Adjustment, ATPase )

Explanation

Question 6 of 6

1

The role that Phospholamban plays in regulation of the SR Ca pump is:

Select one of the following:

  • Inhibitory; cancelled when phosphorylated.

  • Inhibitory; reinforced when phosphorylated.

  • Permissive; cancelled when phosphorylated.

  • Permissive; reinforced when phosphorylated.

Explanation

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