Michael Jardine
Quiz by , created more than 1 year ago

Learning objectives: * Understand the difference between cell growth and proliferation * Describe the major events of the cell cycle * Appreciate the roles of cyclins and cyclin-dependent kinases in regulating cell cycle progression * Provide examples of disordered signaling in cancer * Describe checkpoints and how they regulate the correct expression of the cell cycle * Understand the role of apoptosis in preventing inappropriate cell proliferation

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Michael Jardine
Created by Michael Jardine about 7 years ago
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PHSI3012 01-1 Cell Proliferation

Question 1 of 14

1

What is the difference between cell growth and cell proliferation?

Select one of the following:

  • Cell growth = increase in ONE cell's mass/size; Cell proliferation = increase in cell numbers.

  • Cell growth = increase in cell numbers; Cell proliferation = increase in ONE cell's mass/size.

  • No meaningful distinction.
    (/ distinction without substantial difference)
    (/ fuck all)

Explanation

Question 2 of 14

1

Which of the following is true?

Select one of the following:

  • Control of cell proliferation is intrinsically linked to cell growth.

  • Control of cell growth is intrinsically linked to cell proliferation.

Explanation

Question 3 of 14

3

The order of the rough phases of the cell cycle are as follows:
G1 > > > > (then back to G1 again)

Drag and drop to complete the text.

    S
    G2
    M
    Cytokinesis

Explanation

Question 4 of 14

2

G1 phase stands for, and involves, what?

Select one or more of the following:

  • Growth phase

  • Gap phase

  • Cell growth

  • Monitoring

  • Mitosis

Explanation

Question 5 of 14

2

G2 phase stands for, and involves, what?

Select one or more of the following:

  • Growth phase

  • Gap phase

  • Cell growth

  • Monitoring

  • Mitosis

Explanation

Question 6 of 14

2

S phase stands for, and involves, what?

Select one or more of the following:

  • DNA synthesis

  • Selectivity

  • Cell growth

  • Mitosis

  • Stretching

Explanation

Question 7 of 14

2

M phase stands for, and involves, what?

Select one or more of the following:

  • Mitosis

  • Meiosis

  • Monitoring

  • DNA synthesis

  • Cell division

Explanation

Question 8 of 14

1

Cdks (Cyclin-Dependent KinaseS) are regulated by:

Select one of the following:

  • Cyclins

  • Phosphorylation

  • Both of the above

  • [none of the above]

Explanation

Question 9 of 14

1

Mitogens are:

Select one of the following:

  • Things that stimulate cell division (e.g. hormones, cytokines).

  • Stimulate migration.

Explanation

Question 10 of 14

1

Disordered signaling in cancer.
Many cancer-critical genes (oncogenes or tumour-suppressor genes) regulate cell growth and proliferation.
e.g. a mutation may lead to independence from mitogen-dependence.

Acquiring the ability to synthesise mitogens (resulting in autocrine stimulation) is one way this can happen. Some examples of this are:

Select one of the following:

  • PDGF, TGFα - glioblastomas & osteosarcoma

  • EGF-R/erbB (epidermal growth factor receptor); HER2 (human epidermal growth factor receptor)

Explanation

Question 11 of 14

1

Disordered signaling in cancer.
Many cancer-critical genes (oncogenes or tumour-suppressor genes) regulate cell growth and proliferation.
e.g. a mutation may lead to independence from mitogen-dependence.

Constitutive expression of their receptors (resulting in increased sensitivity?) is one way this can happen. Some examples of this are:

Select one of the following:

  • PDGF, TGFα - glioblastomas & osteosarcoma

  • EGF-R/erbB (epidermal growth factor receptor); HER2 (human epidermal growth factor receptor)

Explanation

Question 12 of 14

1

HER2 (Human Epidermal growth factor Receptor) mutations are present in:

Select one of the following:

  • Overexpressed in breast cancer.

  • Overexpressed in stomach, brain, and breast cancer.

  • Abnormally present in glioblastomas and osteosarcoma.

Explanation

Question 13 of 14

1

EGF-R / erbB (Epidermal Growth Factor Receptor) and cancer...

Select one of the following:

  • Up-regulated in stomach, brain, and breast cancer.

  • Up-regulated in breast cancer.

  • Abnormally present in gliobastomas & osteosarcoma.

Explanation

Question 14 of 14

1

True or false: Mitogens [usually?] act through the ras/raf/ERK cascade.

Select one of the following:

  • True
  • False

Explanation

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