Kathleen Jackson
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Nursing Quiz on 1807NRS Safe Administration of Medications 2, created by Kathleen Jackson on 01/10/2017.

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Kathleen Jackson
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1807NRS Safe Administration of Medications 2

Question 1 of 30

1

Pharmacodynamics involves the study of following EXCEPT:

Select one of the following:

  • Biological and therapeutic effects of drugs

  • Absorption and distribution of drugs

  • Mechanisms of drug action

  • Drug interactions

Explanation

Question 2 of 30

1

Pharmacodynamics involves the study of following?

Select one of the following:

  • Mechanisms of drug action

  • Biotransformation of drugs in the organism

  • Distribution of drugs in the organism

  • Excretion of drug from the organism

Explanation

Question 3 of 30

1

Pharmacodynamics involves the following?

Select one of the following:

  • Information about main mechanisms of drug absorption

  • Information about unwanted effects

  • Information about biological barriers

  • Information about excretion of a drug from the organism

Explanation

Question 4 of 30

1

Pick out the answer which is the most appropriate to the term “receptor”

Select one of the following:

  • All types of ion channels modulated by a drug

  • Enzymes of oxidizing-reducing reactions activated by a drug

  • Active macromolecular components of a cell or an organism which a drug molecule has to combine with in order to elicit its specific effect

  • Carriers activated by a drug

Explanation

Question 5 of 30

1

What does “affinity” mean?

Select one of the following:

  • A measure of how tightly a drug binds to plasma proteins

  • A measure of how tightly a drug binds to a receptor

  • A measure of inhibiting potency of a drug

  • A measure of bioavailability of a drug

Explanation

Question 6 of 30

1

Target proteins which a drug molecule binds are:

Select one of the following:

  • Only receptors

  • Only ion channels

  • Only carriers

  • All answers are correct

Explanation

Question 7 of 30

1

An agonist is a substance that:

Select one of the following:

  • Interacts with the receptor without producing any effect

  • Interacts with the receptor and initiates changes in cell function, producing various effects

  • Increases concentration of another substance to produce effect

  • Interacts with plasma proteins and doesn’t produce any effect

Explanation

Question 8 of 30

1

If an agonist can produce maximal effects and has high efficacy it’s called:

Select one of the following:

  • Partial agonist

  • Antagonist

  • Agonist-antagonist

  • Full agonist

Explanation

Question 9 of 30

1

If an agonist can produce submaximal effects and has moderate efficacy it’s called:

Select one of the following:

  • Partial agonist

  • Antagonist

  • Agonist-antagonist

  • Full agonist

Explanation

Question 10 of 30

1

An antagonist is a substance that:

Select one of the following:

  • Binds to the receptors and initiates changes in cell function, producing maximal effect

  • Binds to the receptors and initiates changes in cell function, producing submaximal effect

  • Interacts with plasma proteins and doesn’t produce any effect

  • Binds to the receptors without directly altering their functions

Explanation

Question 11 of 30

1

A competitive antagonist is a substance that:

Select one of the following:

  • Interacts with receptors and produces submaximal effect

  • Binds to the same receptor site and progressively inhibits the agonist response

  • Binds to the nonspecific sites of tissue

  • Binds to one receptor subtype as an agonist and to another as an antagonist

Explanation

Question 12 of 30

1

The substance binding to one receptor subtype as an agonist and to another as an antagonist is called:

Select one of the following:

  • Competitive antagonist

  • Irreversible antagonist

  • Agonist-antagonist

  • Partial agonist

Explanation

Question 13 of 30

1

Irreversible interaction of an antagonist with a receptor is due to:

Select one of the following:

  • Ionic bonds

  • Hydrogen bonds

  • Covalent bonds

  • All answers are correct

Explanation

Question 14 of 30

1

Mechanisms of transmembrane signaling are the following EXCEPT:

Select one of the following:

  • Transmembrane receptors that bind and stimulate a protein tyrosine kinase

  • Gene replacement by the introduction of a therapeutic gene to correct a genetic effect

  • Ligand-gated ion channels that can be induced to open or close by binding a ligand

  • Transmembrane receptor protein that stimulates a GTP-binding signal transducer protein (G-protein) which in turn generates an intracellular second messenger

Explanation

Question 15 of 30

1

Tick the second messenger of G-protein-coupled (metabotropic) receptor:

Select one of the following:

  • Adenylyl cyclase

  • Sodium ions

  • Phospholipase C

  • cAMP

Explanation

Question 16 of 30

1

Tick the substance which changes the activity of an effector element but doesn’t belong to second messengers:

Select one of the following:

  • cAMP

  • cGMP

  • G–protein

  • Calcium ions

Explanation

Question 17 of 30

1

Give the definition for a therapeutical dose:

Select one of the following:

  • The amount of a substance to produce the minimal biological effect

  • The amount of a substance to produce effects hazardous for an organism

  • The amount of a substance to produce the required effect in most patients

  • The amount of a substance to accelerate an increase of concentration of medicine in an organism

Explanation

Question 18 of 30

1

Pick out the correct definition of a toxic dose:

Select one of the following:

  • The amount of substance to produce the minimal biological effect

  • The amount of substance to produce effects hazardous for an organism

  • The amount of substance to produce the necessary effect in most of patients

  • The amount of substance to fast creation of high concentration of medicine in an organism

Explanation

Question 19 of 30

1

Which effect may lead to toxic reactions when a drug is taken continuously or repeatedly?

Select one of the following:

  • Refractoriness

  • Cumulative effect

  • Tolerance

  • Tachyphylaxis

Explanation

Question 20 of 30

1

What term is used to describe a decrease in responsiveness to a drug which develops in a few minutes?

Select one of the following:

  • Refractoriness

  • Cumulative effect

  • Tolerance

  • Tachyphylaxis

Explanation

Question 21 of 30

1

Idiosyncratic reaction of a drug is:

Select one of the following:

  • A type of hypersensitivity reaction

  • A type of drug antagonism

  • Unpredictable, inherent, qualitatively abnormal reaction to a drug

  • Quantitatively exaggerated response

Explanation

Question 22 of 30

1

Characteristic unwanted reaction which isn’t related to a dose or to a pharmacodynamic property of a drug is called:

Select one of the following:

  • Idiosyncrasy

  • Hypersensitivity

  • Tolerance

  • Teratogenic action

Explanation

Question 23 of 30

1

If two drugs with the same effect, taken together, produce an effect that is equal in magnitude to the sum of the effects of
the drugs given individually, it is called as:

Select one of the following:

  • Antagonism

  • Potentiation

  • Additive effect

  • None of the answers are correct

Explanation

Question 24 of 30

1

What phenomenon can occur in case of using a combination of drugs?

Select one of the following:

  • Tolerance

  • Tachyphylaxis

  • Accumulation

  • Synergism

Explanation

Question 25 of 30

1

What is the type of drug-to-drug interaction which is the result of interaction at receptor, cell, enzyme or organ level?

Select one of the following:

  • Pharmacodynamic interaction

  • Physical and chemical interaction

  • Pharmaceutical interaction

  • Pharmacokinetic interaction

Explanation

Question 26 of 30

1

What is the type of drug-to-drug interaction which is connected with processes of absorption, biotransformation,
distribution and excretion?

Select one of the following:

  • Pharmacodynamic interaction

  • Physical and chemical interaction

  • Pharmaceutical interaction

  • Pharmacokinetic interaction

Explanation

Question 27 of 30

1

The situation when failure to continue administering the drug results in serious psychological and somatic disturbances is called?

Select one of the following:

  • Tachyphylaxis

  • Sensibilization

  • Abstinence syndrome

  • Idiosyncrasy

Explanation

Question 28 of 30

1

Tolerance and drug resistance can be a consequence of:

Select one of the following:

  • Drug dependence

  • Increased metabolic degradation

  • Depressed renal drug excretion

  • Activation of a drug after hepatic first-pass

Explanation

Question 29 of 30

1

Tolerance and drug resistance can be a consequence of:

Select one of the following:

  • Change in receptors, loss of them or exhaustion of mediators

  • Increased receptor sensitivity

  • Decreased metabolic degradation

  • Decreased renal tubular secretion

Explanation

Question 30 of 30

1

Tolerance develops because of:

Select one of the following:

  • Diminished absorption

  • Rapid excretion of a drug

  • Both answers are correct

  • No answer is correct

Explanation

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