Michael Jardine
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PHSI3011 12-1 Comparative physiology and thermal physiology #1

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Michael Jardine
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PHSI3011 12-1 Comparative Physiology and Thermal #1

PHSI3011 12-1 Comparative Physiology and Thermal #1

Question 1 of 17

1

GnIH means what?

Select one of the following:

  • Gonadotropin Inducing Hormone

  • Gonadotropin Inhibitory Hormone

Explanation

Question 2 of 17

1

Gonadotropin Inhibitory Hormone (GnIH) first discovered in 2000 in what model?

Select one of the following:

  • Birds

  • Mice

  • Fish

  • Salamanders

Explanation

Question 3 of 17

1

What does GnIH appear to be the “signaller” for in humans?

Select one of the following:

  • Stress-related suppression of reproduction

  • Menopause

  • Puberty

  • Pregnancy-induced placentation changes

Explanation

Question 4 of 17

1

GnIH is also called:

Select one of the following:

  • RFamide-Related Peptide-3

  • FRamide-Related Peptide-3

  • RFamide-Related Peptide-1

  • FRamide-Related Peptide-1

Explanation

Question 5 of 17

1

True or false: GnIH has been found within the NERVOUS SYSTEMS of animals with all major phyla.

Select one of the following:

  • True
  • False

Explanation

Question 6 of 17

1

GnIH is:

Select one of the following:

  • Usually released into the portal system, but not in some animals (rats, mice).

  • Released into the portal system, but only in some animals (rats, mice).

Explanation

Question 7 of 17

1

A major similarity between organisms is that GnIH is always localised in the:

Select one of the following:

  • Dorsomedial nucleus of the hypothalamus

  • Dorsomedial nucleus of the hippocampus

  • Dorsal horn of the hypothalamus

  • Dorsal horn of the hippocampus

Explanation

Question 8 of 17

1

True or false: A major similarity between organisms is that GnIH neurons project to GnRH cells in all mammalian species studied.

Select one of the following:

  • True
  • False

Explanation

Question 9 of 17

1

True or false: A major similarity between organisms is that GnIH neurons project into the neurosecretory zone of the median eminence in all mammalian species studied.

Select one of the following:

  • True
  • False

Explanation

Question 10 of 17

1

Advantages of using LAB AND DOMESTICATED animals as models include:
(select all that apply)

Select one or more of the following:

  • Well-adapted to labs

  • Detailed knowledge of genetic background

  • Transgenic manipulation allows specific focus

  • Short generation time (longitudinal studies simple and comprehensive)

Explanation

Question 11 of 17

1

An example of a “Wild” species used as a model is the Tree shrew. What is it used to model?

Select one of the following:

  • PTSD

  • Alzheimer’s

  • Cystic Fibrosis

  • Developmental disorders

Explanation

Question 12 of 17

1

Alzheimer’s Disease (AD) is characterised by progressive loss of cholinergic neurons projecting from the basal forebrain to which areas:
(select all that apply)

Select one or more of the following:

  • Cortical

  • Hippocampal

  • Hypothalamic

Explanation

Question 13 of 17

1

The two main histopathological hallmarks of Alzheimer’s Disease (AD) are:
(select the two that apply)

Select one or more of the following:

  • Extracellular senile plaques containing amyloid-beta (Aβ) which is formed after sequential cleavage of Amyloid Precursor Protein (APP) by the catalytic activity of β-secretases and γ-secretases

  • Intracellular Neurofibrillary Tangles (NFTs)

Explanation

Question 14 of 17

1

True or false: A disadvantage of using transgenic models of AD is that many are “icon” species and therefore politically unsuitable.

Select one of the following:

  • True
  • False

Explanation

Question 15 of 17

1

Which of the following wild animals could be candidates as AD models? (but aren’t because of reasons)
(select all that apply)

Select one or more of the following:

  • Wolverines

  • Dolphins

  • Polar Bears

  • Tasmanian Tigers

  • Tasmanian Devils

Explanation

Question 16 of 17

1

The best [non-transgenic, anyway] model for Alzheimer's Disease (AD) is the:

Select one of the following:

  • Degu (Octodon degus)

  • Guinea pig (Cavia porcellus)

  • Naked mole-rat (Heterocephalus glaber)

  • Domestic dog (Canis familiaris)

  • Fat-tailed dunnart (Sminthopsis crassicaudata)

Explanation

Question 17 of 17

1

What age do Degus start presenting Alzheimer’s symptoms?

Select one of the following:

  • ~3-4 years

  • ~4-5 years

  • ~5-6 years

  • ~6-7 years

Explanation

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